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Epidemiology of metabolic syndrome.
Pflugers Arch
January 2025
Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
The global increase of overweight and obesity in children and adults is one of the most prominent public health threats, often accompanied by insulin resistance, hypertension, and dyslipidemia. The simultaneous occurrence of these health problems is referred to as metabolic syndrome. Various criteria have been proposed to define this syndrome, but no general consensus on the specific markers and the respective cut-offs has been achieved yet.
View Article and Find Full Text PDFNumerical Modelling of Hybrid Polymer Composite Frame for Selected Construction Parts and Experimental Validation of Mechanical Properties.
Polymers (Basel)
January 2025
Department of Material Science and Manufacturing Technology, Faculty of Engineering, Czech University of Life Sciences Prague, Kamycka 129, 16500 Prague, Czech Republic.
This article is a numerical and experimental study of the mechanical properties of different glass, flax and hybrid composites. By utilizing hybrid composites consisting of natural fibers, the aim is to eventually reduce the percentage usage of synthetic or man-made fibers in composites and obtain similar levels of mechanical properties that are offered by composites using synthetic fibers. This in turn would lead to greener composites being utilized.
View Article and Find Full Text PDFMulti-scenario land use change simulation and spatial-temporal evolution of carbon storage in the Yangtze River Delta region based on the PLUS-InVEST model.
PLoS One
January 2025
College of Geography and Environmental Sciences, Zhejiang Normal University, Jinhua, China.
Influenced by urban expansion, population growth, and various socio-economic activities, land use in the Yangtze River Delta (YRD) area has undergone prominent changes. Modifications in land use have resulted in adjustments to ecological structures, leading to subsequent fluctuations in carbon storage. This study focuses on YRD region and analyzes the characteristics of land use changes in the area using land use data from 2000 to 2020, with a 10-year interval.
View Article and Find Full Text PDFSample Size Adjustment in Sequential Multiple Assignment Randomized Trials.
Stat Med
February 2025
Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY.
Clinical trials are often designed based on limited information about effect sizes and precision parameters with risks of underpowered studies. This is more problematic for SMARTs where strategy effects are based on sequences of treatments. Sample size adjustment offers flexibility through re-estimating sample size during the trial to ensure adequate power at the final analysis.
View Article and Find Full Text PDFCost-effectiveness of data driven personalised antibiotic dosing in critically ill patients with sepsis or septic shock.
J Clin Monit Comput
January 2025
Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health research institute, Van der Boechorststraat 7, Amsterdam, 1081 BT, the Netherlands.
Purpose: This study provides an economic evaluation of bedside, data-driven, and model-informed precision dosing of antibiotics in comparison with usual care among critically ill patients with sepsis or septic shock.
Methods: This economic evaluation was conducted alongside an AutoKinetics randomized controlled trial. Effect measures included quality-adjusted life years (QALYs), mortality and pharmacokinetic target attainment.
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