AI Article Synopsis
- The immune system is essential for detecting and destroying cancer cells to prevent tumor growth.
- Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) are the primary immune cells responsible for killing tumor cells through different activation mechanisms but similar cytotoxic processes.
- The review discusses the specific ways these immune cells induce cell death in tumors, focusing on mechanisms like death ligands and granulysin, and explores current therapeutic strategies derived from these processes.
Article Abstract
The immune system plays a key role in cancer immune surveillance to control tumor development. The final goal is recognizing and killing transformed cells and consequently the elimination of the tumor. The main effector cell types exerting cytotoxicity against tumors are natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). Although the mechanism of activation of NK cells and CTLs are quite different, both cell types share common antitumor effector mechanisms of cytotoxicity which lead to induction of cell death of tumor cells by apoptosis. Among these mechanisms are the death ligand- and granulysin-mediated cell deaths. In this review, we summarize the main concepts of these effector cytotoxic mechanisms against cancer cells, how NK cells and CTLs use them to control tumor development and the therapeutic approaches currently developed based on these molecules.
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| http://dx.doi.org/10.2217/imt.15.56 | DOI Listing |
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