2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd(II)-catalyzed meta-C(sp(2))-H alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573956 | PMC |
| http://dx.doi.org/10.1021/jacs.5b08914 | DOI Listing |
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