Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673108 | PMC |
| http://dx.doi.org/10.18632/oncotarget.4756 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Article Synopsis
- PMN-MDSCs are dysfunctional immune cells that hinder the effectiveness of cancer immunotherapy, particularly by affecting the immune response in gastric cancer.
- The study developed a fusion protein, TFF2-MSA, that acts as a partial agonist for the CXCR4 receptor, enhancing the effects of anti-PD-1 therapy to reduce tumor growth and improve survival in various gastric cancer models.
- TFF2-MSA specifically reduces harmful PMN-MDSCs while keeping helpful neutrophils intact, which boosts the CD8 T cell-mediated anti-tumor response, contrasting with traditional CXCR4 antagonism that did not show similar benefits.
Cardiovascular risks in Asian HIV-infected patients receiving boosted-protease inhibitor-based antiretroviral treatment.
J Infect Dev Ctries
March 2021
NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Introduction: Increased risk of cardiovascular disease in HIV-infected patients was tought to be the cause of multiple mechanistic factors, which changing the HIV care landscape. Antiretroviral therapy (ART), especially protease inhibitors (PI), is one of common HIV treatments that may have some association with this. The mechanism of PI in comparison to other regimens, however, are not clearly understood.
View Article and Find Full Text PDFEmerging Biomarkers of Oxidative Stress in Acute and Stable Coronary Artery Disease: Levels and Determinants.
Antioxidants (Basel)
May 2019
Fondazione CNR-Regione Toscana G Monasterio, 56100 Pisa, Italy.
Background: Oxidative stress is crucial in the pathogenesis of atherosclerosis and acute myocardial infarction (AMI). Under the generic terms "oxidative stress" (OS), many biomarkers belonging to different pathways have been proposed.
Aim: To compare the levels of recently proposed OS-related parameters in acute coronary syndromes (ACS) and stable coronary artery disease (CAD), to evaluate their effectiveness as additive risk or illness indicators of stable and acute ischemic events, and their response over time during the course of AMI.
C-terminus of heat shock protein 60 can activate macrophages by lectin-like oxidized low-density lipoprotein receptor 1.
Biochem Biophys Res Commun
January 2019
Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address:
Immune responses against antigens generally require an efficient activation of antigen-presenting cells (APCs). Currently, the targeting of vaccine antigens to APCs has emerged as a promising strategy for boosting vaccine immunogenicity. Here, we reported that the C-terminus of heat shock protein 60 (HSP60C) can activate mouse peritoneal macrophages to secret a series of cytokines, and phosphorylation of p38 mitogen-activated protein kinase (MAPK) and NF-κB p65 was involved in the pathway.
View Article and Find Full Text PDFExpression and Characterization of a Single-Chain Variable Fragment against Human LOX-1 in and .
J Microbiol Biotechnol
May 2017
School of Life Science, Jilin University, Changchun, Jilin 130012, P.R. China.
The single-chain variable fragment (scFv) against lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a promising molecule for its potential use in the diagnosis and immunotherapy of atherosclerosis. Producing this scFv in several milligram amounts could be the starting point for further engineering and application of the scFv. In this study, the abundant expression of the anti-LOX-1 scFv was attempted using () and .
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!