Associations between Lectin-like, oxidized low-density lipoprotein receptor-1 G501C and 3'-UTR-C188T polymorphisms with coronary artery disease: a meta-analysis.

Unlabelled: The background and purpose: Published data on the association between LOX-1 3'UTR C188T and G501C polymorphisms with coronary artery disease (CAD) risk are inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was conducted.

Methods And Subjects: Crude ORs with 95% CIs were used to assess the strength of association between these polymorphisms and CAD risk. The pooled ORs were performed for homozygous model, heterozygous model, dominant model, and recessive model, respectively.

Results: A total of seventeen studies were involved in the meta-analysis with 5006 cases and 15053 controls for LOX-1 3'UTR C188T polymorphism and with 5905 cases and 15050 controls for G501C polymorphism. For LOX-1 3'UTR C188T polymorphism, significantly elevated CAD risk was associated with variant genotype when all studies were pooled into the meta-analysis (TT vs. CC: OR = 1.35, 95% CI 1.08-1.69; dominant model: OR = 1.17, 95% CI 1.02-1.34; and recessive model: OR = 1.23, 95% CI 1.03-1.47). For LOX-1 G501C polymorphism, significantly increased CAD risk was also associated with variant genotype (GG vs. CC: OR = 1.42, 95% CI 1.07-1.87; CG vs. CC: OR = 1.28, 95% CI 1.04-1.56; and dominant model: OR = 1.30, 95% CI 1.07-1.58).

Conclusion: This meta-analysis suggests that the variant G allele of LOX1 3'UTR C188T and the variant C allele of G501C polymorphisms are low penetrant risk factors for developing CAD.