Previous research had indicated that the smoking of medium tar and nicotine (T/N) yield cigarettes produced a psychostimulant action on electroencephalographic (EEG) activity which was apparent after a single cigarette and was evident as early as the fourth puff. The present study adopted the identical smoking and recording procedure to examine whether low-T/N yield cigarettes produced qualitatively similar EEG profiles as previously observed with medium-yield cigarettes. Although the results indicated similarities in post-smoking EEG profiles of low- and medium-yield cigarettes, discrepancies with several EEG components and temporal (puff-by-puff) EEG features suggested that low-yield cigarettes may exert less impact on brain electric activity. The results are discussed in relation to motivational theories of smoking behavior.
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http://dx.doi.org/10.1159/000118580 | DOI Listing |
Metabolites
March 2024
Upland Flue-Cured Tobacco Quality & Ecology Key Laboratory of CNTC, Guizhou Academy of Tobacco Science, Guiyang 550081, China.
The quality of crops is closely associated with their geographical location and yield, which is reflected in the composition of their metabolites. Hence, we employed GC-MS pseudotargeted metabolomics to investigate the metabolic characteristics of high-, medium-, and low-yield (tobacco) leaves from the Bozhou (sweet honey flavour) and Shuicheng (light flavour) regions of Guizhou Province. A total of 124 metabolites were identified and classified into 22 chemical categories.
View Article and Find Full Text PDFPhytochemistry
November 2020
Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center, Russian Academy of Sciences, P.O. Box 30, Kazan, 420111, Russia. Electronic address:
The CYP74 family of cytochromes P450 includes four enzymes of fatty acid hydroperoxide metabolism: allene oxide synthase (AOS), hydroperoxide lyase (HPL), divinyl ether synthase (DES), and epoxyalcohol synthase (EAS). The present work is concerned with catalytic specificities of three recombinant DESs, namely, the 9-DES (LeDES, CYP74D1) of tomato (Solanum lycopersicum), 9-DES (NtDES, CYP74D3) of tobacco (Nicotiana tabacum), and 13-DES (LuDES, CYP74B16) of flax (Linum usitatissimum), as well as their alterations upon the site-directed mutagenesis. Both LeDES and NtDES converted 9-hydroperoxides of linoleic and α-linolenic acids to divinyl ethers colneleic and colnelenic acids (respectively) with only minorities of HPL and EAS products.
View Article and Find Full Text PDFProtoplasma
November 2020
Molecular Cell Biology, Botanical Institute, Karlsruhe Institute of Technology, Karlsruhe, Germany.
The potential of pharmacologically active secondary plant metabolites is limited by the low yield from often rare plants, and the lack of economically feasible chemical synthesis of these complex compounds. Plant cell fermentation offers an alternative strategy to overcome these constraints. However, the efficiency of this approach is limited by intracellular sequestration of the products, such that continuous bioprocessing is not possible.
View Article and Find Full Text PDFPrev Med
November 2020
Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN, United States.
Tobacco harm reduction remains a controversial topic in tobacco control. Tobacco harm reduction involves providing tobacco users who are unwilling or unable to quit using nicotine products with less harmful nicotine-containing products for continued use. The skepticism towards harm reduction is based in part on the experience with low-yield tar/nicotine cigarettes, which were presumed to be associated with lower health risks than higher yield cigarettes and marketed as such by cigarette manufacturers.
View Article and Find Full Text PDFRegul Toxicol Pharmacol
April 2018
Department of Public Health Sciences, Graduate School, Korea University, Seoul, Republic of Korea. Electronic address:
A total of 38 hazardous constituents in mainstream cigarette smoke of low-yield cigarettes sold in Korea were selected and analyzed using established methods. Risk calculations were performed using risk algorithms employed in previous studies and Korean population-based exposure parameters. The median cumulative incremental lifetime cancer risk of male smokers could vary from 828 × 10 to 2510 × 10, and that of female smokers could range from 440 × 10 to 1300 × 10, depending on the smoking regimens.
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