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Does fat suppression via chemically selective saturation affect R2*-MRI for transfusional iron overload assessment? A clinical evaluation at 1.5T and 3T. | LitMetric

AI Article Synopsis

  • The study investigates how fat suppression (FS) using chemically selective saturation (CHESS) affects the measurement of R2* in MRI, particularly in patients with excessive liver iron content (LIC).
  • It was found that CHESS systematically reduced R2* values at 1.5T, especially for higher iron levels, which could impact clinical assessments.
  • A proposed correction model successfully adjusted for this bias, potentially improving the accuracy of diagnosing liver iron overload in clinical settings.

Article Abstract

Purpose: Fat suppression (FS) via chemically selective saturation (CHESS) eliminates fat-water oscillations in multiecho gradient echo (mGRE) R2*-MRI. However, for increasing R2* values as seen with increasing liver iron content (LIC), the water signal spectrally overlaps with the CHESS band, which may alter R2*. We investigated the effect of CHESS on R2* and developed a heuristic correction for the observed CHESS-induced R2* changes.

Methods: Eighty patients [female, n = 49; male, n = 31; mean age (± standard deviation), 18.3 ± 11.7 y] with iron overload were scanned with a non-FS and a CHESS-FS mGRE sequence at 1.5T and 3T. Mean liver R2* values were evaluated using three published fitting approaches. Measured and model-corrected R2* values were compared and statistically analyzed.

Results: At 1.5T, CHESS led to a systematic R2* reduction (P < 0.001 for all fitting algorithms) especially toward higher R2*. Our model described the observed changes well and reduced the CHESS-induced R2* bias after correction (linear regression slopes: 1.032/0.927/0.981). No CHESS-induced R2* reductions were found at 3T.

Conclusion: The CHESS-induced R2* bias at 1.5T needs to be considered when applying R2*-LIC biopsy calibrations for clinical LIC assessment, which were established without FS at 1.5T. The proposed model corrects the R2* bias and could therefore improve clinical iron overload assessment based on linear R2*-LIC calibrations. Magn Reson Med 76:591-601, 2016. © 2015 Wiley Periodicals, Inc.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769126PMC
http://dx.doi.org/10.1002/mrm.25868DOI Listing

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