AI Article Synopsis
- Liraglutide is an analogue of GLP-1 used for treating diabetes and obesity; the study aimed to create a once-weekly version with better stability and albumin affinity.
- Semaglutide was identified as the best candidate, modified with two amino acid changes and a specific derivation to enhance its effectiveness.
- Compared to liraglutide, semaglutide has a lower GLP-1R affinity but greater albumin affinity, leading to a longer plasma half-life and is currently undergoing phase 3 clinical tests.
Article Abstract
Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) analogue that binds to serum albumin in vivo and is approved for once-daily treatment of diabetes as well as obesity. The aim of the present studies was to design a once weekly GLP-1 analogue by increasing albumin affinity and secure full stability against metabolic degradation. The fatty acid moiety and the linking chemistry to GLP-1 were the key features to secure high albumin affinity and GLP-1 receptor (GLP-1R) potency and in obtaining a prolonged exposure and action of the GLP-1 analogue. Semaglutide was selected as the optimal once weekly candidate. Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib(8), Arg(34)) and is derivatized at lysine 26. The GLP-1R affinity of semaglutide (0.38 ± 0.06 nM) was three-fold decreased compared to liraglutide, whereas the albumin affinity was increased. The plasma half-life was 46.1 h in mini-pigs following i.v. administration, and semaglutide has an MRT of 63.6 h after s.c. dosing to mini-pigs. Semaglutide is currently in phase 3 clinical testing.
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| http://dx.doi.org/10.1021/acs.jmedchem.5b00726 | DOI Listing |
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