AI Article Synopsis
- The auditory nerve transmits hearing information from sensory hair cells to the brain, and traditionally, damage to it in adults is considered permanent, leading to sensorineural hearing loss.
- Researchers studied a mouse model and found that after neuronal degeneration, glial cells in the auditory nerve became activated and showed signs of neurogenesis, indicating potential for regeneration.
- They identified neural stem/progenitor cells in these glial populations and discovered that injury and low oxygen levels can stimulate the growth of these nerve cells, highlighting a possible path for repairing auditory nerve damage.
Article Abstract
The auditory nerve is the primary conveyor of hearing information from sensory hair cells to the brain. It has been believed that loss of the auditory nerve is irreversible in the adult mammalian ear, resulting in sensorineural hearing loss. We examined the regenerative potential of the auditory nerve in a mouse model of auditory neuropathy. Following neuronal degeneration, quiescent glial cells converted to an activated state showing a decrease in nuclear chromatin condensation, altered histone deacetylase expression and up-regulation of numerous genes associated with neurogenesis or development. Neurosphere formation assays showed that adult auditory nerves contain neural stem/progenitor cells (NSPs) that were within a Sox2-positive glial population. Production of neurospheres from auditory nerve cells was stimulated by acute neuronal injury and hypoxic conditioning. These results demonstrate that a subset of glial cells in the adult auditory nerve exhibit several characteristics of NSPs and are therefore potential targets for promoting auditory nerve regeneration.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549618 | PMC |
| http://dx.doi.org/10.1038/srep13383 | DOI Listing |
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