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Deep Learning-Enabled Assessment of Right Ventricular Function Improves Prognostication After Transcatheter Edge-to-Edge Repair for Mitral Regurgitation.
Circ Cardiovasc Imaging
January 2025
DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance (M.L., A.H., E.R., M.v.S., A. Kastrati, H.S., M.J., E.X., K.-L.L., J.H., T.T.).
Background: Right ventricular (RV) function has a well-established prognostic role in patients with severe mitral regurgitation (MR) undergoing transcatheter edge-to-edge repair (TEER) and is typically assessed using echocardiography-measured tricuspid annular plane systolic excursion. Recently, a deep learning model has been proposed that accurately predicts RV ejection fraction (RVEF) from 2-dimensional echocardiographic videos, with similar diagnostic accuracy as 3-dimensional imaging. This study aimed to evaluate the prognostic value of the deep learning-predicted RVEF values in patients with severe MR undergoing TEER.
View Article and Find Full Text PDF3-dimensional investigation of the vascular anatomy of the triquetrum with micro-computed tomography.
Ann Anat
January 2025
Department of Anatomy, Ankara University School of Medicine, Ankara, Turkey. Electronic address:
Background: This study aims to demonstrate the 3-dimensional pattern of the nutrient vessels of the triquetrum using micro-computed tomography and determine the safe region for screw applications to the bone.
Methods: Seven fresh frozen cadavers' ulnar and radial arteries were injected with Microfil MV-117. Triquetral bones were dissected and examined using micro-computed tomography.
Action of the Euclidean versus projective group on an agent's internal space in curiosity driven exploration.
Biol Cybern
January 2025
CIAMS, Université Paris-Saclay, Orsay & Université d'Orléans, Orléans, France.
According to the Projective Consciousness Model (PCM), in human spatial awareness, 3-dimensional projective geometry structures information integration and action planning through perspective taking within an internal representation space. The way different perspectives are related to and transform a world model defines a specific perception and imagination scheme. In mathematics, such a collection of transformations corresponds to a 'group', whose 'actions' characterize the geometry of a space.
View Article and Find Full Text PDFRNA Translocation through Protein Nanopores: Interlude of the Molten RNA Globule.
J Am Chem Soc
January 2025
Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003, United States.
Direct translocation of RNA with secondary structures using single-molecule electrophoresis through protein nanopores shows significant fluctuations in the measured ionic current, in contrast to unstructured single-stranded RNA or DNA. We developed a multiscale model combining the oxRNA model for RNA with the 3-dimensional Poisson-Nernst-Planck formalism for electric fields within protein pores, aiming to map RNA conformations to ionic currents as RNA translocates through three protein nanopores: α-hemolysin, CsgG, and MspA. Our findings reveal three distinct stages of translocation (pseudoknot, melting, and molten globule) based on contact maps and current values.
View Article and Find Full Text PDFReinnervation of Free Nipple Grafts Associated With Improved Erection Function.
Plast Reconstr Surg Glob Open
January 2025
From the Division of Plastic and Reconstructive Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Background: Most patients undergoing breast surgery with free nipple grafts lose nipple erection (NE) function. This study aimed to evaluate the effect of nerve preservation and reconstruction with targeted nipple-areola complex reinnervation (TNR) on NE following gender-affirming mastectomy with free nipple grafting.
Methods: Patients undergoing gender-affirming mastectomy with free nipple grafts were prospectively enrolled.
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