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Novel Methods to Assess Tumor Burden and Minimal Residual Disease in Genitourinary Cancers.
Eur Urol
December 2024
Department of Cancer Medicine and INSERM U981, Université Paris-Sud, Université Paris-Saclay, Gustave Roussy, Villejuif, France.
Article Synopsis
- Advances in molecular diagnostics are transforming how prostate, renal, and urothelial cancers are assessed, offering more accurate detection methods for disease burden and minimal residual disease (MRD).
- A literature review from 1980-2024 highlights emerging radiographic and molecular tools aimed at improving disease quantification and monitoring through innovative technologies and biomarker-informed trials.
- New developments, like novel radiotracers and molecular detection methods (e.g., circulating tumor DNA), provide insights into disease mechanisms and have the potential to enhance clinical management, although full MRD application is still in progress.
Increasing our knowledge about the epidemiology of in Nunavik's Inuit population (Québec, Canada) using 2017 cross-sectional survey.
Int J Circumpolar Health
December 2024
Département de médecine sociale et préventive, Université Laval, Québec, Québec, Canada.
Article Synopsis
- A bacterium can grow in the human stomach, causing chronic inflammation, peptic ulcers, and cancer, and this study focuses on its prevalence among Nunavik's Inuit population using data from 2004 and 2017.
- The study found high rates of colonization (70.9%) and associated issues like gastritis (11.2%) and peptic ulcers (2.4%), with few cases of gastric cancer reported.
- Factors influencing higher colonization included the number of people in a household and age, while drinking municipal or natural water and lower alcohol consumption were linked to reduced colonization rates.
Longitudinal genomic analysis of Neisseria gonorrhoeae transmission dynamics in Australia.
Nat Commun
September 2024
Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
N. gonorrhoeae, which causes the sexually transmissible infection gonorrhoea, remains a significant public health threat globally, with challenges posed by increasing transmission and antimicrobial resistance (AMR). The COVID-19 pandemic introduced exceptional circumstances into communicable disease control, impacting the transmission of gonorrhoea and other infectious diseases.
View Article and Find Full Text PDFMinimally Invasive Management of Inguinal Lymph Nodes in Penile Cancer: Recent Progress and Remaining Challenges.
Cancers (Basel)
August 2024
Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA.
Article Synopsis
- The diagnosis of occult inguinal lymph node metastasis in invasive penile squamous cell carcinoma (PSCC) is difficult and has high surgical complications.
- Recent advances in dynamic sentinel lymph node biopsy (DSLNB) show better diagnostic accuracy and fewer complications than traditional methods, but its use is still limited.
- Laparoscopic and robotic-assisted inguinal lymph node dissection (ILND) offer alternative approaches that reduce infection and pain, yet variations in treatment remain due to the rarity of PSCC and lack of large-scale studies.
Ultrasonographic findings in the bladder of cattle at different stages of evolution of bovine enzootic hematuria in Brazil.
Res Vet Sci
November 2024
Faculty of Veterinary Medicine, Universidade Federal Fluminense (UFF), Niterói, RJ, Brazil.
Despite the diagnostic capacity of ultrasonography (US) in cases of bovine enzootic hematuria (BEH), it has been underused in the medical clinic for ruminants. Studies comparing ultrasound findings in healthy animals (HA) with subclinical (SCH) and clinical (CH) BEH are scarce in the literature. As a result, the present work aims to describe the US findings of cattle at different stages of BEH evolution, evaluating the diagnostic capacity and precocity of the technique.
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