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Viral-host molecular interactions and metabolic modulation: Strategies to inhibit flaviviruses pathogenesis.
World J Virol
December 2024
Department of Obstetrics and Gynecology, Ewha Womans University, Seoul 07985, South Korea.
Flaviviruses, which include globally impactful pathogens, such as West Nile virus, yellow fever virus, Zika virus, Japanese encephalitis virus, and dengue virus, contribute significantly to human infections. Despite the ongoing emergence and resurgence of flavivirus-mediated pathogenesis, the absence of specific therapeutic options remains a challenge in the prevention and treatment of flaviviral infections. Through the intricate processes of fusion, transcription, replication, and maturation, the complex interplay of viral and host metabolic interactions affects pathophysiology.
View Article and Find Full Text PDFClimate-driven dengue fever outbreaks in Nepal: Trends, challenges, and strategies.
World J Virol
December 2024
Research Section, Nepal Health Research Council, Kathmandu 44600, Bagmati, Nepal.
Dengue fever (DF) has become a major public health concern in Nepal, with increasing outbreaks in recent years. Transmitted by Aedes mosquitoes, this climate-sensitive viral disease presents a significant challenge for healthcare providers and policymakers. Since 2004, Nepal has experienced a sharp increase in DF cases, peaking in 2022 with 54784 cases and 88 deaths.
View Article and Find Full Text PDF[Targets and mechanisms of neutralizing monoclonal antibodies against Dengue virus].
Sheng Wu Gong Cheng Xue Bao
December 2024
CAS Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Dengue fever is a mosquito-borne disease prevalent in tropical and subtropical regions, with its prevalence expanding due to increased global travel. The dengue virus, the causative agent of dengue fever, often co-circulates in the form of four distinct serotypes. Cross-reactive antibodies generated during a primary infection pose a significant risk during secondary infections with different serotypes, and fully protective vaccines and antiviral drugs are yet to be developed.
View Article and Find Full Text PDFRapid human movement and dengue transmission in Bangladesh: a spatial and temporal analysis based on different policy measures of COVID-19 pandemic and Eid festival.
Infect Dis Poverty
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Ecosystem Change and Population Health Research Group, Centre for Immunology and Infection Control, School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, Brisbane, QLD, 4059, Australia.
Background: Rapid human movement plays a crucial role in the spatial dissemination of the dengue virus. Nevertheless, robust quantification of this relationship using both spatial and temporal models remains necessary. This study aims to explore the spatial and temporal patterns of dengue transmission under various human movement contexts.
View Article and Find Full Text PDFDengue in France in 2024 - A year of record numbers of imported and autochthonous cases.
New Microbes New Infect
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University of Zürich, Epidemiology, Biostatistics and Prevention Institute, Hirschengraben 84, 8001, Zürich, Switzerland.
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