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Comprehensive analysis of 111 Pleuronectiformes mitochondrial genomes: insights into structure, conservation, variation and evolution.
BMC Genomics
January 2025
Institute of Aquatic Biotechnology, College of Life Sciences, Qingdao University, Qingdao, Shandong, 266071, China.
Background: Pleuronectiformes, also known as flatfish, are important model and economic animals. However, a comprehensive genome survey of their important organelles, mitochondria, has been limited. Therefore, we aim to analyze the genomic structure, codon preference, nucleotide diversity, selective pressure and repeat sequences, as well as reconstruct the phylogenetic relationship using the mitochondrial genomes of 111 flatfish species.
View Article and Find Full Text PDFp-Type Sensing of DNA Nucleobases Adsorbed on Graphene Nanoribbon.
ACS Omega
January 2025
Department of Physics, Lehigh University, Bethlehem, Pennsylvania 18015, United States.
DNA nucleobases are important in DNA sequencing, disease testing linked to genes, and disease treatment. Here, we report density functional calculations investigating the adsorption of guanine (G), adenine (A), thymine (T), and cytosine (C) on armchair graphene nanoribbons (AGNR) - a gapped semiconductor. Their adsorption energies, charge transfer, work function, and electrical properties were calculated.
View Article and Find Full Text PDFUnderstanding the structural and functional diversity of ATP-PPases using protein domains and functional families in the CATH database.
Structure
January 2025
Department of Structural and Molecular Biology, University College London, London, UK. Electronic address:
ATP-pyrophosphatases (ATP-PPases) are the most primordial lineage of the large and diverse HUP (high-motif proteins, universal stress proteins, ATP-pyrophosphatase) superfamily. There are four different ATP-PPase substrate-specificity groups (SSGs), and members of each group show considerable sequence variation across the domains of life despite sharing the same catalytic function. Owing to the expansion in the number of ATP-PPase domain structures from advances in protein structure prediction by AlphaFold2 (AF2), we have characterized the two most populated ATP-PPase SSGs, the nicotinamide adenine dinucleotide synthases (NADSs) and guanosine monophosphate synthases (GMPSs).
View Article and Find Full Text PDFInvestigating the impact of Multiwalled Carbon Nanotubes exposure on enzymatic activities and histopathological variations in Swiss albino mice.
Sci Rep
January 2025
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
Present study was conducted to evaluate the detrimental impacts of exposure of Multi-walled Carbon Nanotubes (MWCNT-NP) on enzymatic activities and tissue structures in Swiss albino mice. The experimental groups of mice received MWCNT-NP for specific time period (seven or fourteen days). Two distinct doses of the MWCNT-NP solution were given orally: 0.
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