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Recent research progress on microRNAs from mesenchymal stem cell-derived exosomes for tumor therapy: A review.
J Cancer Res Ther
December 2024
Department of Pathology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, China.
Mesenchymal stem cells (MSCs) are a class of protocells that can differentiate into various cell types and have robust replication and renewal capabilities. MSCs secrete various nutritional factors to regulate the microenvironment of tumor tissues. The mechanism by which they inhibit or promote tumor growth may be closely related to MSC-derived exosomes (MSC-Exo).
View Article and Find Full Text PDFDifferent association of HDL-C, apoA-I, and HDL-C/apoA-I with multiple outcomes in HFrEF patients.
Int J Cardiol
December 2024
Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China; Nanhai Translational Innovation Center of Precision Immunology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Foshan 528200, China; Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou 510120, China. Electronic address:
Background: High-density lipoprotein-cholesterol (HDL-C) has been considered a cardioprotective factor for several decades. However, its association with outcomes in patients with heart failure with reduced ejection fraction (HFrEF) remains controversial. We aimed to investigate the association of HDL-C, apolipoprotein A-I (apoA-I), and the HDL-C/apoA-I ratio with multiple outcomes of HFrEF patients and establish prognostic models using machine learning methods.
View Article and Find Full Text PDFCaffeine and Arrhythmias: A Critical Analysis of Cardiovascular Responses and Arrhythmia Susceptibility.
J Saudi Heart Assoc
November 2024
Department of Electrophysiology, Mohammed Bin Khalifa Bin Salman Al Khalifa Cardiac Centre, Awali, Bahrain.
Caffeine is a frequently consumed stimulant in different foods and beverages: coffee, tea, chocolate, sodas, and energy drinks. While its effects on the cardiovascular system have been extensively studied, there remains controversy surrounding its potential risks, particularly in patients with heart disease. This review provides a complete overview of caffeine's pharmacological properties, sources, and cardiovascular effects, particularly emphasizing its arrhythmogenic potential.
View Article and Find Full Text PDFOptimal timing of oral anticoagulation initiation in patients with acute ischaemic stroke and atrial fibrillation: a comprehensive meta-analysis and systematic review.
Open Heart
November 2024
Electrophysiology, University of South Florida, Tampa, Florida, USA.
Article Synopsis
- - The study investigates the optimal timing for starting direct oral anticoagulants (DOACs) for stroke prevention in patients with atrial fibrillation and acute ischaemic stroke, comparing early initiation (around 3.5 days) to later initiation (about 5.7 days) due to concerns about bleeding risks.
- - An analysis of 11 studies, including 13,020 participants, found that early initiation of DOACs resulted in significantly lower rates of recurrent ischaemic stroke and intracranial hemorrhage compared to the late group.
- - While key outcomes like major hemorrhage and all-cause mortality showed no significant differences between the groups, the variability in the study designs and limited number of RCT
The association between adipokines dysregulation and the occurrence of atrial fibrillation and obese patients, is it relevant?
Arch Cardiol Mex
November 2024
Electrophysiology and Arrhythmias Service, 20 de Noviembre National Medical Center, Institute of Social Security and Services for State Workers, Mexico City, México.
Atrial fibrillation (AF) is the most common arrhythmia, affecting approximately 33.5 millions of people worldwide. Unfortunately, the prevalence of this arrhythmia will increase within the following two decades, resulting in a higher mortality rate and a higher economic burden for public health services.
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