AI Article Synopsis
- - The study investigates how oxidative stress affects fine motor skills, visual processing, and behavior in children undergoing chemotherapy for acute lymphoblastic leukemia (ALL) over the course of treatment.
- - Findings revealed that, while visual processing speed improved by the end of therapy, fine motor skills and visual-motor integration remained below average, with oxidative stress linked to these deficits and associated behavioral issues like hyperactivity and anxiety.
- - The research emphasizes the need for early intervention strategies to address potential fine motor and visual-spatial challenges and behavioral problems in children receiving chemotherapy.
Article Abstract
Purpose/objectives: To examine associations among oxidative stress, fine and visual-motor abilities, and behavioral adjustment in children receiving chemotherapy for acute lymphoblastic leukemia (ALL)
.
Design: A prospective, repeated-measures design
.
Setting: Two pediatric oncology settings in the southwestern United States.
Sample: 89 children with ALL were followed from diagnosis to the end of chemotherapy.
Methods: Serial cerebrospinal fluid samples were collected during scheduled lumbar punctures and analyzed for oxidative stress biomarkers. Children completed fine motor dexterity, visual processing speed, and visual-motor integration measures at three time points. Parents completed child behavior ratings at the same times.
Main Research Variables: Oxidative stress, fine motor dexterity, visual processing, visual-motor integration, and behavioral adjustment
.
Findings: Children with ALL had below-average fine motor dexterity, visual processing speed, and visual-motor integration following the induction phase of ALL therapy. By end of therapy, visual processing speed normalized, and fine motor dexterity and visual-motor integration remained below average. Oxidative stress measures correlated with fine motor dexterity and visual-motor integration. Decreased motor functioning was associated with increased hyperactivity and anxiety
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Conclusions: Oxidative stress occurs following chemo-therapy for childhood ALL and is related to impaired fine motor skills and visual symptoms
.
Implications For Nursing: Early intervention should be considered to prevent fine motor and visual-spatial deficits, as well as behavioral problems.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551112 | PMC |
| http://dx.doi.org/10.1188/15.ONF.542-549 | DOI Listing |
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