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Therapeutic drug monitoring of perospirone: The lowest effective plasma concentration in patients with schizophrenia.
Asian J Psychiatr
December 2023
Xi'an Mental Health Center, 710100 Xi'an, PR China. Electronic address:
Objectives: This study investigated the effects of demographic factors such as age, sex and comedications on the plasma concentrations of perospirone in individuals diagnosed with schizophrenia. Additionally, the relationship between these plasma levels and the clinical efficacy of the medication was explored.
Methods: Data regarding the plasma concentration of perospirone in patients with schizophrenia were obtained from the Xi'an Mental Health Center and were retrospectively analysed.
Exploration of interaction interface of TRKβ/BDNF through fingerprint analysis to disinter potential agonists.
Mol Divers
June 2024
Department of Biotechnology, M S Ramaiah Institute of Technology, Bangalore, Karnataka, 560054, India.
Tyrosine Kinase beta (TRKβ), is a type I membrane receptor which plays a major role in various signalling pathways. TRKβ was found to be upregulated in various cancers and contrastingly downregulated in various neurodegenerative disorders. Hitherto, contemporary drug research is oriented towards discovery of TRKβ inhibitors, thus neglecting the development of TRKβ agonists.
View Article and Find Full Text PDFAntihyperalgesic effects of intrathecal perospirone in a rat model of neuropathic pain.
Pharmacol Biochem Behav
August 2020
Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu 807-8555, Japan.
The descending serotonergic pathway, from the brainstem to spinal cord, modulates various aspects of pain processing. The spinal 5-hydroxytryptamine (5-HT) and 5-HT receptors play pivotal roles in pain modulation. Perospirone is a novel atypical antipsychotic that serves as a 5-hydroxytryptamine (5-HT) receptor agonist, a 5-HT receptor antagonist, and a dopamine D receptor antagonist.
View Article and Find Full Text PDFPerospirone Exhibits Antiemetic Efficacy against Opioid-Induced Nausea in Patients with Advanced Cancer.
J Palliat Med
October 2015
1 Department of Palliative Medicine, National Cancer Center Hospital, Tokyo, Japan .
Two cases of mild serotonin toxicity via 5-hydroxytryptamine 1A receptor stimulation.
Neuropsychiatr Dis Treat
March 2014
Department of Psychiatry, National Defense Medical College, Saitama, Japan.
We propose the possibility of 5-hydroxytryptamine (5-HT)1A receptor involvement in mild serotonin toxicity. A 64-year-old woman who experienced hallucinations was treated with perospirone (8 mg/day). She also complained of depressed mood and was prescribed paroxetine (10 mg/day).
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