Objective: To investigate the expression and prognostic value of miR-224 expression in patients with diffuse large B-cell lymphoma (DLBCL) who underwent R-CHOP.
Materials And Methods: RT-PCR was used to determine the relative expression of miR-224, in 258 DLBCL patients and 40 normal lymphoid tissue specimens.
Results: MiR-224 expression in DLBCL patients was significantly down-regulated compared to that in negative controls (p < 0.05). The 5-year progression-free survival and overall survival rates were significantly higher in the high-expression level group compared to the low-expression level group (p < 0.05).
Conclusions: MiR-224 expression level is implicated as a prognostic marker for DLBCL patients treated with R-CHOP.
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| http://dx.doi.org/10.3109/1354750X.2015.1068855 | DOI Listing |
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