AI Article Synopsis
- Researchers isolated seven new phenylcoumarin compounds from the fruits of Mesua lepidota, named lepidotols A-E and lepidotins A and B, using methods like UV, NMR, and HRMS to determine their structures.
- The main compound, lepidotol A, was studied for its effects on inflammation and immune responses in endothelial cells, showing significant anti-inflammatory activity at a concentration of 10 μM.
- Lepidotol A effectively reduced the expression of specific adhesion molecules linked to inflammation and also demonstrated mild immunosuppressive effects on major histocompatibility complex molecules.
Article Abstract
Phytochemical investigation on the fruits of Mesua lepidota (Calophyllaceae) led to the isolation of seven new phenylcoumarin derivatives named lepidotols A-E (1-5) and lepidotins A and B (6, 7). These structures were elucidated by spectroscopic and spectrometric methods including UV, NMR, and HRMS. Lepidotol A (1), the major compound, was evaluated for its inhibitory effect on inflammation and immunity using endothelial cell-based cellular assays. At 10 μM, 1 exhibited an anti-inflammatory activity, with a significant inhibition of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 expression induced by tumor necrosis factor-α. Lepidotol A also showed a mild immunosuppressive effect, with inhibition of the major histocompatibility complex molecules, namely, human leukocyte antigen (HLA)-DR and HLA-E.
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| http://dx.doi.org/10.1021/acs.jnatprod.5b00222 | DOI Listing |
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Article Synopsis
- Researchers isolated seven new phenylcoumarin compounds from the fruits of Mesua lepidota, named lepidotols A-E and lepidotins A and B, using methods like UV, NMR, and HRMS to determine their structures.
- The main compound, lepidotol A, was studied for its effects on inflammation and immune responses in endothelial cells, showing significant anti-inflammatory activity at a concentration of 10 μM.
- Lepidotol A effectively reduced the expression of specific adhesion molecules linked to inflammation and also demonstrated mild immunosuppressive effects on major histocompatibility complex molecules.
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