A new model for educating baccalaureate nurses emerged from the needs of employers and came to fruition through a unique partnership resulting in the development of the 1st competency-based, asynchronous single-curriculum prelicensure program in the United States. Three nurse executives championed the design and implementation of the multistate approach to preparing RNs (MAP RN) program. The nationally accredited program has been initiated in 5 states.
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Identification of key factors related to digital health observational study adherence and retention by data-driven approaches: an exploratory secondary analysis of two prospective longitudinal studies.
Lancet Digit Health
January 2025
Biomedical Engineering Department, Duke University, Durham, NC, USA; Biostatistics and Bioinformatics Department, Duke University, Durham, NC, USA. Electronic address:
Background: Longitudinal digital health studies combine passively collected information from digital devices, such as commercial wearable devices, and actively contributed data, such as surveys, from participants. Although the use of smartphones and access to the internet supports the development of these studies, challenges exist in collecting representative data due to low adherence and retention. We aimed to identify key factors related to adherence and retention in digital health studies and develop a methodology to identify factors that are associated with and might affect study participant engagement.
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J Cancer Surviv
December 2024
College of Nursing, Chungnam National University, 266 Munhwa-Ro, Jung-Gu, Daejeon, South Korea, 35015.
Purpose: Frailty is a major concern in the aging cancer population. It can progress to severe frailty or death or improve to pre-frail or non-frail states. However, frailty transitions in older cancer survivors are not well understood.
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Biom J
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Product Development Data Sciences, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
When planning an oncology clinical trial, the usual approach is to assume proportional hazards and even an exponential distribution for time-to-event endpoints. Often, besides the gold-standard endpoint overall survival (OS), progression-free survival (PFS) is considered as a second confirmatory endpoint. We use a survival multistate model to jointly model these two endpoints and find that neither exponential distribution nor proportional hazards will typically hold for both endpoints simultaneously.
View Article and Find Full Text PDFBayesian subtyping for multi-state brain functional connectome with application on preadolescent brain cognition.
Biostatistics
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Department of Biostatistics, Yale University, 300 George St, New Haven, CT 06520, United States.
Converging evidence indicates that the heterogeneity of cognitive profiles may arise through detectable alternations in brain functional connectivity. Despite an unprecedented opportunity to uncover neurobiological subtypes through clustering or subtyping analyses on multi-state functional connectivity, few existing approaches are applicable to accommodate the network topology and unique biological architecture. To address this issue, we propose an innovative Bayesian nonparametric network-variate clustering analysis to uncover subgroups of individuals with homogeneous brain functional network patterns under multiple cognitive states.
View Article and Find Full Text PDFAssessment of Drug Impact on Laboratory Test Results in Hospital Settings.
Pac Symp Biocomput
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The Disease Systems Biology Group, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, Copenhagen, 2200, Denmark.
Patients experiencing adverse drug events (ADE) from polypharmaceutical regimens present a huge challenge to modern healthcare. While computational efforts may reduce the incidence of these ADEs, current strategies are typically non-generalizable for standard healthcare systems. To address this, we carried out a retrospective study aimed at developing a statistical approach to detect and quantify potential ADEs.
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