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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535043PMC
http://dx.doi.org/10.1177/2045125315584869DOI Listing

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Article Synopsis
  • The use of melatonin as an over-the-counter supplement has increased due to more people experiencing sleep-wake disorders, especially during the post-COVID-19 era.
  • This systematic review investigates the effectiveness and side effects of melatonin for migraine prevention, comparing it to standard treatments and placebos, based on data from seven high-quality randomized control trials with 1,283 participants.
  • Findings suggest that melatonin may significantly reduce migraine frequency and severity, though its specific dosage and additional benefits, such as weight control, need further investigation.
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Background: Migraine is a headache disorder that affects public health and reduces the patient's quality of life. Preventive medication is necessary to prevent acute attacks and medication overuse headaches (MOH). Agomelatine is a melatonin antagonist.

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Despite plenty of effective antidepressant (AD) treatments, the outcome of major depressive disorder (MDD) is often unsatisfactory, probably due to improvable exploitation of available therapies. This European, cross-sectional, naturalistic multicenter study investigated the frequency of additional psychotherapy in terms of a manual-driven psychotherapy (MDP) in 1410 adult in- and outpatients with MDD, who were primarily treated with AD psychopharmacotherapy. Socio-demographic and clinical patterns were compared between patients receiving both treatments and those lacking concomitant MDP.

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