AI Article Synopsis
- The study aims to improve the differentiation between Alzheimer's disease (AD), mild cognitive impairment (MCI), and normal control (NC) using a multi-modality approach.
- Researchers developed a new classification method called weighted multi-modality sparse representation-based classification (wmSRC) that integrates various types of neuroimaging data.
- The wmSRC method achieved high accuracy rates in classifying AD and MCI, suggesting it could enhance the detection and treatment approach for these conditions.
Article Abstract
Background And Objective: The discrimination of Alzheimer's disease (AD) and its prodromal stage known as mild cognitive impairment (MCI) from normal control (NC) is important for patients' timely treatment. The simultaneous use of multi-modality data has been demonstrated to be helpful for more accurate identification. The current study focused on extending a multi-modality algorithm and evaluating the method by identifying AD/MCI.
Methods: In this study, sparse representation-based classification (SRC), a well-developed method in pattern recognition and machine learning, was extended to a multi-modality classification framework named as weighted multi-modality SRC (wmSRC). Data including three modalities of volumetric magnetic resonance imaging (MRI), fluorodeoxyglucose (FDG) positron emission tomography (PET) and florbetapir PET from the Alzheimer's disease Neuroimaging Initiative database were adopted for AD/MCI classification (113 AD patients, 110 MCI patients and 117 NC subjects).
Results: Adopting wmSRC, the classification accuracy achieved 94.8% for AD vs. NC, 74.5% for MCI vs. NC, and 77.8% for progressive MCI vs. stable MCI, superior to or comparable with the results of some other state-of-the-art models in recent multi-modality researches.
Conclusions: The wmSRC method is a promising tool for classification with multi-modality data. It could be effective for identifying diseases from NC with neuroimaging data, which could be helpful for the timely diagnosis and treatment of diseases.
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| http://dx.doi.org/10.1016/j.cmpb.2015.08.004 | DOI Listing |
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