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| http://dx.doi.org/10.18632/aging.100788 | DOI Listing |
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Sulforaphane Suppresses the Growth of Triple-negative Breast Cancer Stem-like Cells and .
Cancer Prev Res (Phila)
March 2019
Nutritional Science Research Group, Division of Cancer Prevention, NCI, Rockville, Maryland.
Triple-negative breast cancer (TNBC) represents the poorest prognosis among all of breast cancer subtypes with no currently available effective therapy. In this study, we hypothesized that sulforaphane, a dietary component abundant in broccoli and its sprouts, can inhibit malignant cell proliferation and tumor sphere formation of cancer stem-like cells (CSC) in TNBC. CSC population was isolated using FACS analysis with the combined stem cell surface markers, CD44/CD24/CD49f The effect of sulforaphane on a stem-related embryonic oncogene CRIPTO-1/TDGF1 (CR1) was evaluated via ELISA.
View Article and Find Full Text PDFDevelopmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer.
Breast Cancer Res Treat
April 2016
Tumor Growth Factor Section, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Building 560, Room 32-40B, 1050 Boyles Street, Ft. Detrick, Frederick, MD, 21702, USA.
Cancer has been considered as temporal and spatial aberrations of normal development in tissues. Similarities between mammary embryonic development and cell transformation suggest that the underlying processes required for mammary gland development are also those perturbed during various stages of mammary tumorigenesis and breast cancer (BC) development. The master regulators of embryonic development Cripto-1, Notch/CSL, and Wnt/β-catenin play key roles in modulating mammary gland morphogenesis and cell fate specification in the embryo through fetal mammary stem cells (fMaSC) and in the adult organism particularly within the adult mammary stem cells (aMaSC), which determine mammary progenitor cell lineages that generate the basal/myoepithelial and luminal compartments of the adult mammary gland.
View Article and Find Full Text PDFCripto-1 in TNBC.
Aging (Albany NY)
August 2015
Tumor Growth Factor Section, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA.
Cripto-1 as a novel therapeutic target for triple negative breast cancer.
Oncotarget
May 2015
Tumor Growth Factor Section, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA.
Article Synopsis
- Triple-negative breast cancer (TNBC) has the worst prognosis and lacks effective standard treatment.
- A mouse model was used to study TNBC's characteristics, revealing tumors that mimic actual TNBC in both form and molecular profile.
- The study identified Cripto-1 as a potential target for treatment, as its knockout inhibited tumor growth and metastasis, suggesting new avenues for TNBC therapies.
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