AI Article Synopsis
- The SMAP subfamily of Arf GTPase-activating proteins in mammals includes closely related proteins, SMAP1 and SMAP2, which have different roles in membrane trafficking.
- Research shows that knocking out both SMAP1 and SMAP2 in mice leads to cell death in early embryos (E7.5) and likely causes the embryos to not survive.
- The findings suggest that at least one of the SMAP proteins is essential for normal embryonic development.
Article Abstract
In mammals, the small Arf GTPase-activating protein (SMAP) subfamily of Arf GTPase-activating proteins consists of closely related members, SMAP1 and SMAP2. These factors reportedly exert distinct functions in membrane trafficking, as manifested by different phenotypes seen in single knockout mice. The present study investigated whether SMAP proteins interact genetically. We report for the first time that simultaneous loss of SMAP1 and SMAP2 promotes apoptosis in the distal region of E7.5 mouse embryos, likely resulting in embryonic lethality. Thus, at least one SMAP gene, either SMAP1 or SMAP2, is required for proper embryogenesis.
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| http://dx.doi.org/10.1016/j.febslet.2015.07.050 | DOI Listing |
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