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| http://dx.doi.org/10.1136/bcr-2015-212137 | DOI Listing |
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Long Term Fate of Testis Prosthesis after Metoidioplasty and Phalloplasty.
Urology
December 2024
Crane Center for Transgender Surgery, 4407 Bee Caves Rd, Ste 612 Austin TX 78746, USA.
Objectives: To identify specific complications associated with testicle prosthesis at our dedicated transgender surgery center, over a long follow up period exceeding 5 years.
Methods: We conducted a retrospective chart review of all transmasculine patients undergoing testicular implants after metoidioplasty or phalloplasty between January 2016 to November 2019, stopping the series in 2019 to allow at least 3 year follow up.
Results: 23 patients were identified, 16 (70%) of whom had a prior metoidioplasty and 7 (30%) with prior phalloplasty receiving only testicular implants (no penile implant).
An extragenital cell population contributes to urethra closure during mouse penis development.
Sci Adv
December 2024
Reproductive Developmental Biology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
The penis, the organ that bears reproductive and psychological importance, is susceptible to birth defects such as hypospadias or incomplete closure of urethra along the penis shaft. We discover that proper urethral closure in mouse embryos requires a unique mesenchymal cell population originated from outside of the penis. These "extragenital" cells, marked by a lineage marker , migrate from the inguinal region into the embryonic penis and facilitate urethra closure by interacting with adjacent periurethral cells via the epidermal growth factor pathway.
View Article and Find Full Text PDFSystematic comparison of fluorescence imaging in the near-infrared and shortwave-infrared spectral range using clinical tumor samples containing cetuximab-IRDye800CW.
J Biomed Opt
January 2025
University Medical Centre Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen, The Netherlands.
Article Synopsis
- Shortwave-infrared (SWIR) imaging is suggested to improve contrast in fluorescence-guided surgery compared to near-infrared (NIR) imaging, but it has only been tested in animal studies so far.
- The study aims to evaluate the benefits of SWIR imaging in clinical samples treated with the NIR dye cetuximab-IRDye800CW, focusing on tumor-targeted applications in penile and head and neck cancers.
- Results indicate that while SWIR performs similarly to NIR in penile cancer samples, NIR outperforms SWIR in most criteria for head and neck cancer due to high background autofluorescence, suggesting that SWIR may enhance contrast in some situations but not universally across all clinical
Classification of epidermal, buccal, penile and vaginal epithelial cells using morphological characteristics measured by imaging flow cytometry.
Forensic Sci Int
December 2024
College of Science and Engineering, Flinders University, Adelaide, South Australia 5042, Australia. Electronic address:
As a result of the increased sensitivity of forensic DNA techniques, which can generate informative results from as little as a few cells, developing an understanding of the anatomical region these cells originate from is becoming more pertinent. Imaging Flow Cytometry (IFC) represents a promising method for identifying epithelial cells from different anatomical regions. This project aimed to determine whether IFC could be used to distinguish epithelial cells collected from different forensically relevant anatomical regions based on their morphology and autofluorescence.
View Article and Find Full Text PDFPseudomyogenic hemangioendothelioma presenting as a penile lesion.
Virchows Arch
December 2024
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Pseudomyogenic hemangioendothelioma (PHE) is a rare, usually multifocal neoplasm typically affecting individuals in the second-to-fourth decade of life, with a male predominance. It often arises in the distal extremities and characteristically involves multiple tissue planes. Presentation of this neoplasm as a primary penile lesion is exceedingly rare, with only five cases previously documented in the literature.
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