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We report the challenges in managing a troubled, medically ill adolescent with end-of-life issues. Our role as multi-professional service providers complemented the family's efforts to help him reconcile with himself before death. The present experience enhances understanding of the biopsychosocial aspects of care. Every child has the right to optimal care.
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http://dx.doi.org/10.1111/ped.12693 | DOI Listing |
Adv Sci (Weinh)
March 2025
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.
Synthetic lethality in homologous recombination (HR)-deficient cancers caused by Poly (ADP-ribose) polymerase inhibitors (PARPi) has been classically attributed to its role in DNA repair. The mode of action of PARPi and resistance thereof are now believed to be predominantly replication associated. Therefore, effective combinatorial approaches of targeting replication fork processing along with HR-downregulation to target HR-proficient and possibly PARPi-resistant tumors are warranted.
View Article and Find Full Text PDFBMC Cardiovasc Disord
March 2025
Department of General Medicine, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Aim: Ischemic heart disease (IHD) is a major contributor to global mortality and disability, imposing a significant health and economic burden on patients and society. Despite existing treatment options including medications and surgeries, their effectiveness remains limited, with issues such as suboptimal treatment outcomes and high recurrence rates. This study aims to investigate the relationship between low dietary intake of ω-3 fatty acids and the burden of IHD, hoping to provide new insights into the prevention and treatment of IHD.
View Article and Find Full Text PDFSci Rep
March 2025
School of Computer Science, Zhuhai College of Science and Technology, Ankee Road East, Zhuhai, 519040, Guangdong, China.
Fire disasters pose significant risks to human life, economic development, and social stability. The early stages of a fire, often characterized by small flames, diffuse smoke, and obstructed objects, can lead to challenges such as missed detections and poor real-time performance. To address these issues, we propose a DSS-YOLO model based on an improved YOLOv8n architecture, designed to enhance the recognition accuracy of obscured objects and small targets while reducing computational overhead.
View Article and Find Full Text PDFValue Health Reg Issues
March 2025
National Health Observatory, National Institute of Health, Bogotá, D.C., Colombia.
Objectives: Accurate estimates of years of life lost (YLLs) are necessary to assess the management of diabetes mellitus (DM) and to understand the burden of the disease on society. We aimed to quantify the impact of mortality because of DM by estimating the YLLs in Colombia between 1979 and 2017.
Methods: An ecological study was conducted using mortality data from the National Administrative Department of Statistics of Colombia.
Cell Tissue Bank
March 2025
Department of Pediatric Surgery, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Burn injuries in children are a critical public health issue with significant mortality and morbidity. Allogeneic skin grafts, both cadaveric and freshly donated, have been utilized in pediatric burn care since many years, yet their efficacy and safety remain to be systematically assessed. This systematic review (PROSPERO number: CRD42024560654) analyzed studies from 01/2000 to 07/2024 sourced from PubMed.
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