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Venous Endothelial Cell Transcriptomic Profiling Implicates METAP1 in Preeclampsia.
Circ Res
December 2024
Cardiovascular Research Center, Massachusetts General Hospital, Boston. (C.C., P.X., Z.Y., Y.S., E.S.L., J.D.R., M.C.H.).
Background: Preeclampsia is a hypertensive disorder of pregnancy characterized by systemic endothelial dysfunction. The pathophysiology of preeclampsia remains incompletely understood. This study used human venous endothelial cell (EC) transcriptional profiling to investigate potential novel mechanisms underlying EC dysfunction in preeclampsia.
View Article and Find Full Text PDFAdvancing diagnosis in a cardiac arrest case and suspected MINOCA: the complementary roles of imaging, biopsy, and genetic testing.
Eur Heart J Imaging Methods Pract
July 2024
Cardiology and Arrhythmology Clinic, Marche University Hospital, Via Conca 71, 60020 Ancona, Italy.
Loeys-Dietz Syndrome Presenting with an Abdominal Aortic Aneurysm: A Case Report.
Ann Vasc Dis
December 2024
Division of Vascular Surgery, Department of Cardiovascular Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Loeys-Dietz syndrome (LDS) is a genetic connective tissue disorder associated with vascular involvement and craniofacial, skeletal, and cutaneous abnormalities. Herein, we describe the case of a 28-year-old female who presented with a pulsatile mass in her abdomen. Imaging studies revealed multiple aneurysms, including a 53-mm abdominal aortic aneurysm (AAA) and tortuosity of the intracranial arterial vasculature.
View Article and Find Full Text PDFUtility of Duplex Ultrasound in the Diagnosis and Treatment of Functional Popliteal Artery Entrapment Syndrome.
Ann Vasc Dis
December 2024
Department of Vascular Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
A 19-year-old female presented with intermittent claudication without anatomical abnormality in the popliteal fossa on magnetic resonance imaging and computed tomography. However, duplex ultrasound (DUS) showed compression of the popliteal artery (PA) and vein during plantarflexion and dorsiflexion. She was diagnosed with functional PA entrapment syndrome (PAES) and underwent resection of the plantaris and gastrocnemius muscles using DUS with stress maneuvers, which relieved the symptoms.
View Article and Find Full Text PDFExhaled Nitric Oxide and Sputum Eosinophils Are Complementary Tools for Diagnosing Occupational Asthma.
Allergy
December 2024
Service de Pneumologie, Centre Hospitalier Universitaire UCL Namur, Université Catholique de Louvain, Yvoir, Belgium.
Background: Exposure-related changes in exhaled nitric oxide (FeNO) and sputum eosinophils have not been thoroughly compared in the investigation of occupational asthma.
Objective: This study aimed at comparing the accuracies of the changes in FeNO concentrations and sputum eosinophil counts in identifying asthmatic reactions induced by occupational agents during specific inhalation challenges (SICs).
Methods: This retrospective multicenter study included 321 subjects who completed an assessment of FeNO and sputum eosinophils before and 24 h after SICs with various occupational agents, of whom 156 showed a positive result.
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