AI Article Synopsis
- * The review identifies promising compounds for TB treatment that have low toxicity and strong effectiveness, along with new drug targets in MTB for future research.
- * The overall goal is to summarize recent advancements in antitubercular drug discovery and encourage further exploration of potential treatments.
Article Abstract
Tuberculosis (TB) is an infectious disease caused by bacterium of the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization aims to substantially reduce the number of cases in the coming years; however, the increased number of multidrug-resistant (MDR) and extremely drug-resistant (XDR) forms of the bacterium and the lack of treatment for latent tuberculosis are challenges to be overcome. In this review, we have identified the most potent compounds described in the literature during recent years with MIC values < 7 µM, low toxicity and a high selective index. In addition, emerging targets in MTB are presented to provide new perspectives for the discovery of new antitubercular drugs. This review aims to summarize the current advances in and promote insights into antitubercular drug discovery.
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| http://dx.doi.org/10.2174/0929867322666150818103836 | DOI Listing |
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