AI Article Synopsis
- MSCs have great potential for therapies, but their variability in different environments complicates standardization and assessment of their effectiveness.
- The review suggests specific marker combinations to help identify and expand different MSC subpopulations.
- It also compares mouse and human MSC markers to improve understanding and modeling of MSC biology across species.
Article Abstract
Mesenchymal stem/stromal cells (MSCs) feature promising potential for cellular therapies, yet significant progress in development of MSC therapeutics and assays is hampered because of remarkable MSC heterogeneity in vivo and in vitro. This heterogeneity poses challenges for standardization of MSC characterization and potency assays as well as for MSC study comparability and manufacturing. This review discusses promising marker combinations for prospective MSC subpopulation enrichment and expansion, and reflects MSC phenotype changes due to environment and age. In order to address animal modelling in MSC biology, comparison of mouse and human MSC markers highlights current common ground of MSCs between species.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539918 | PMC |
| http://dx.doi.org/10.1186/s13287-015-0144-8 | DOI Listing |
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