It was established as a result of cytotoxicity studies of 15 welding dusts of different compositions in experiments on embryonal fibroblast cell cultures that the biologic activity of these substances depends on the solubility in growth media of their major components: alkaline and alkaline earth metals, iron, cremnium and, to a vast degree, that of the manganese. Conclusion has been made that a comparative assessment of welding dusts' biological activity on cell cultures should involve the kinetic parameters of their solubility in growth and supportive media, and the duration of the substances' affecting the cell cultures should be long enough to reveal the combined action of its major ingredients.
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