[IMMUNOGENETICS AND PROGRESSION OF CHRONIC VIRAL HEPATITES]. | LitMetric

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[IMMUNOGENETICS AND PROGRESSION OF CHRONIC VIRAL HEPATITES]. | LitMetric

[IMMUNOGENETICS AND PROGRESSION OF CHRONIC VIRAL HEPATITES].

E V Beloborodova I A Goncharova E I Beloborodova I L Purlik T P Kalacheva O E Akbasheva M I Rachkovskiy V A Burkovskaya

Eksp Klin Gastroenterol

Published: September 2015

Aim Of Investigation: To estimate the role of polymorphic variants of genes IL4 (C-590T), IL4RA (I50V), TNF (G-308A) and SLC1IAI (D543N) in chronic viral hepatitis progression.

Material And Methods: Overall 121 patients with chronic viral hepatitis C and B.

Results: Study results have demonstrated, that of all investigated polymorphic variants of genes IL4 (C-590T), IL4RA (150V), TNF (G-308A) and SLC11A1 (D543N) in patients with chronic liver diseases of various etiology the <> IL4RA gene variant (II50Val) is associated with HBV-infection chronization. The allele <> gene TNF-α (G-308A) is protective for chronic viral hepatitis and is associated with a low level of production by mononuclear cells of TNF-α and IL-12, high secretion of IL-4 and low degree of collagenopathy in the liver. Genotype <> of IL4 (C-590T) gene is an adverse marker for progression of chronic viral hepatitis B. There was significant correlation of polymorphic variants TNF (G-308A) and IL4 (C-590T) genes with production of the key interleukins, that determine type of immune response (Th-1, Th-2) and products of collagen metabolism that testifies genetic determination of system immune response and collagen formation processes in the liver at chronic viral hepatitis.

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