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Indirect determination of hemoglobin A2 reference intervals in Pakistani infants using data mining.
BMC Med Inform Decis Mak
January 2025
Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Stadium Road, Karachi, 74800, Pakistan.
Background: Reference intervals (RIs) are crucial for distinguishing healthy from sick individuals and vary across age groups. Hemoglobinopathies are common in Pakistan, making the quantification of hemoglobin variants essential for screening. Direct RIs are established by measuring values from a healthy reference population, whereas indirect RIs, use statistical analysis of routine lab data to estimate values, making it feasible in settings where direct data is unavailable.
View Article and Find Full Text PDFPsychological and interpersonal dimensions of sexual function and dysfunction: recommendations from the fifth international consultation on sexual medicine (ICSM 2024).
Sex Med Rev
December 2024
Digital Human-Environment Interaction Lab, Department of Psychology, Education and Sports, Lusófona University, Inês Tavares, 4000-098 Porto, Portugal.
Introduction: Sexual health concerns are common and significantly impact quality of life, but many people do not seek treatment due to embarrassment and other barriers. A biopsychosocial model of assessment and treatment acknowledges the biological, psychological, and social contributors to sexual difficulties and suggests that all these domains should be evaluated.
Objectives: This paper provides an overview of the major psychological factors contributing to sexual difficulties and offer an evidence-based approach for primary care clinicians to assess and treat these issues.
Developing a Computational Phenotype of the Fourth Universal Definition of Myocardial Infarction for Inpatients.
J Clin Med
December 2024
Centre for Health Informatics, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada.
: The fourth universal definition of myocardial infarction (MI) introduced the differentiation of acute myocardial injury from MI. In this study, we developed a computational phenotype for distinct identification of acute myocardial injury and MI within electronic medical records (EMRs). : Two cohorts were used from a Calgary-wide EMR system: a chart review of 3042 randomly selected inpatients from Dec 2014 to Jun 2015; and 11,685 episodes of care that included cardiac catheterization from Jan 2013 to Apr 2017.
View Article and Find Full Text PDFDetection of multiple myositis-specific antibodies: prevalence and clinical significance.
Lab Med
January 2025
Immunology Department, Habib Bourguiba University Hospital, University of Sfax, Sfax, Tunisia.
Background: The multipositivity of myositis-specific antibodies (MSAs) is uncommon. Our study aimed to assess the prevalence and the clinical relevance of multiple positive MSAs in routine practice.
Methods: A 10 year single-center retrospective study (2015-2024) was conducted reviewing all samples analyzed with the Dot Myositis EUROLINE (Euroimmun Germany).
Differential effects of fine particulate matter constituents on acute coronary syndrome onset.
Nat Commun
December 2024
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China.
Fine particulate matter has been linked with acute coronary syndrome. Nevertheless, the key constituents remain unclear. Here, we conduct a nationwide case-crossover study in China during 2015-2021 to quantify the associations between fine particulate matter constituents (organic matter, black carbon, nitrate, sulfate, and ammonium) and acute coronary syndrome, and to identify the critical contributors.
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