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New Pyranopyrazole-Based Indolin-2,3-Dione Hybrid as Effective Inhibitors of Xanthine Oxidase: Synthesis, In Vitro, and Molecular Modeling Approaches.
Chem Biodivers
January 2025
Department of Chemistry, Faculty of Science, Taibah University, Medina Manora, Saudi Arabia.
In the current study, new pyranopyrazole analogs (9a-d and 10a-d) were synthesized through a one-pot condensation reaction of 2-arylacetohydrazide. The inhibitory abilities were investigated against the xanthine oxidase (XO) enzyme through experimental and molecular docking analyses. The synthesis studies were based on ultrasound-mediated condensation reactions of four-component containing 2-arylacetohydrazide, ethyl acetoacetate, indoline-2,3-dione, and ethyl 2-cyanoacetate/malononitrile in various solvents and catalysts to yield pyranopyrazole analogs (9a-d and 10a-d) in a short reaction time and remarkably favorable yields ranging from 79% to 92%.
View Article and Find Full Text PDFFecal Metaproteomics as a Tool to Monitor Functional Modifications Induced in the Gut Microbiota by Ketogenic Diet: A Case Study.
Proteomics
January 2025
Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Metaproteomics is a valuable approach to characterize the biological functions involved in the gut microbiota (GM) response to dietary interventions. Ketogenic diets (KDs) are very effective in controlling seizure severity and frequency in drug-resistant epilepsy (DRE) and in the weight loss management in obese/overweight individuals. This case study provides proof of concept for the suitability of metaproteomics to monitor changes in taxonomic and functional GM features in an individual on a short-term very low-calorie ketogenic diet (VLCKD, 4 weeks), followed by a low-calorie diet (LCD).
View Article and Find Full Text PDFRuthenium-Hydride Complexes Facilitated Sustainable Synthesis of Isoxazolones via Acceptorless Dehydrogenative Annulation of Alcohols.
J Org Chem
January 2025
Centre for Organometallic Chemistry, School of Chemistry, Bharathidasan University, Tiruchirappalli 620 024, India.
A streamlined strategy for the one-pot synthesis of isoxazolone analogues has been developed through an acceptorless dehydrogenative annulation (ADA) pathway by employing new Ru(II) hydride complexes as effective catalysts. New Ru(II) complexes () tailored with N̂O chelating carbazolone benzhydrazone ligands were synthesized and their formation was confirmed using analytical and spectral techniques including FT-IR and NMR. The structural configuration of the complexes featuring an octahedral geometry around the Ru(II) ion was precisely determined by single-crystal X-ray diffraction analysis.
View Article and Find Full Text PDFThe Cardioprotective Effects of Nutritional Ketosis: Mechanisms and Clinical Implications.
Nutrients
December 2024
Cardiology Unit, IRCCS INRCA, 60127 Ancona, Italy.
Cardiovascular diseases (CVDs) persist as the primary cause of death worldwide, accounting for roughly 17.9 million fatalities each year. The prevalence of obesity, metabolic syndrome, and type 2 diabetes (key risk factors for CVD) continues to escalate at an alarming rate, necessitating novel therapeutic strategies to address this global health crisis.
View Article and Find Full Text PDFMetabolites and Lipoproteins May Predict the Severity of Early Acute Pancreatitis in a South African Cohort.
Biomedicines
October 2024
Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
Article Synopsis
- Acute pancreatitis (AP) can be severe and unpredictable, and this study explored metabolic and lipoprotein profiles in AP patients of African descent to better understand its pathophysiology for improved prognosis and management.
- Serum samples from 30 AP patients of varying severity and 9 healthy controls were analyzed using nuclear magnetic resonance spectroscopy to identify metabolic signals and lipoprotein characteristics.
- Key findings showed that increased levels of certain metabolites (3-hydroxybutyrate, acetoacetate) and decreased ascorbate correlate with AP severity, while lipid profiles differ from healthy controls, suggesting that these metabolic indicators can help differentiate AP states and inform treatment decisions.
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