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Combination of elastic liposomes and low frequency ultrasound for skin permeation enhancement of hyaluronic acid. | LitMetric

Combination of elastic liposomes and low frequency ultrasound for skin permeation enhancement of hyaluronic acid.

Colloids Surf B Biointerfaces

Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand; The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Commission on High Education, Ministry of Education, Thailand; The Center of Excellence in Medical Biotechnology, Naresuan University, Phitsanulok 65000, Thailand. Electronic address:

Published: November 2015

AI Article Synopsis

  • The study explores a combination of elastic liposomes (ELs) and low-frequency ultrasound (LFU) to enhance the delivery of hyaluronic acid (HA) through the skin, focusing on its effectiveness in delivering hydrophilic macromolecules.
  • HA-loaded ELs were created using varying cholesterol levels, and their size and drug entrapment efficiency were measured, revealing a 77% efficiency and optimal sizes around 700 nm.
  • The combination of ELs and LFU significantly improved HA's permeability compared to using them separately, achieving up to 6.4 times greater delivery, with no skin damage noted at the safe exposure duration of 1 minute.

Article Abstract

Hypothesis: The synergistic approach of using elastic liposomes (ELs) and low frequency ultrasound (LFU) was developed to enhance transepidermal delivery of hydrophilic macromolecules, hyaluronic acid (HA).

Experiment: HA loaded ELs were prepared with varying cholesterol contents by reverse phase evaporation technique. Their mean sizes were evaluated using dynamic light scattering. Entrapment efficacy (%EE) was determined by UV-vis spectrophotometry. In vitro permeation studies using porcine ear epidermis were investigated. In addition, skin barrier disruption was assessed by transepidermal water loss and histology.

Findings: The HA loaded ELs showed mostly elliptical shaped with a mean size of ∼ 700 nm and a zeta potential of ∼-40 mV. Up to 77% drug entrapment efficiency was achieved. As ELs cholesterol content decreased, vesicle size, elasticity of liposomes and HA permeation profile increased. The in vitro permeation studies demonstrated that HA solution cannot permeate through the porcine epidermis. The combination of ELs/LFU showed greater HA permeation than ELs and HA/LFU, 2.1 times and 6.4 times, respectively. Increased LFU exposure times augmented HA permeation, but greater skin disruption was observed. Nevertheless, no skin damage was observed at the optimized 1 min exposure time. This ELs/LFU combination provides an efficacious protocol for transcutaneous drug delivery.

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Source
http://dx.doi.org/10.1016/j.colsurfb.2015.07.078DOI Listing

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