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Development of hepatic pathology in GBV-B-infected red-bellied tamarins (Saguinus labiatus).
J Med Virol
December 2020
Division of Virology, National Institute for Biological Standards and Control, Medicine and Healthcare products Regulatory Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, UK.
GB virus B (GBV-B) is a new world monkey-associated flavivirus used to model acute hepatitis C virus (HCV) infection. Critical for evaluation of antiviral or vaccine approaches is an understanding of the effect of HCV on the liver at different stages of infection. In the absence of longitudinal human tissue samples at defined time points, we have characterized changes in tamarins.
View Article and Find Full Text PDFThe EUPRIM-Net Primates Biobank.
Biopreserv Biobank
August 2015
German Primate Center, Gottingen, Germany .
Alternative methods for the use of non-human primates in biomedical research.
ALTEX
August 2015
Alternatives Unit, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
The experimental use of non-human primates (NHP) in Europe is tightly regulated and is only permitted when there are no alternatives available. As a result, NHP are most often used in late, pre-clinical phases of biomedical research. Although the impetus for scientists, politicians and the general public to replace, reduce and refine NHP in biomedical research is strong, the development of 3Rs technology for NHP poses specific challenges.
View Article and Find Full Text PDFGenome typing of nonhuman primate models: implications for biomedical research.
Trends Genet
November 2014
Gene Bank of Primates and Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.
The success of personalized medicine rests on understanding the genetic variation between individuals. Thus, as medical practice evolves and variation among individuals becomes a fundamental aspect of clinical medicine, a thorough consideration of the genetic and genomic information concerning the animals used as models in biomedical research also becomes critical. In particular, nonhuman primates (NHPs) offer great promise as models for many aspects of human health and disease.
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