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Juvenile dermatomyositis with Anti-SAE antibodies in a Moroccan child associated with pseudo-angioedema: a case report.
Pediatr Rheumatol Online J
May 2024
Dermatology department, CHU SOUSS-MASSA, Agadir, Morocco.
Article Synopsis
- Juvenile Dermatomyositis (JDM) is an autoimmune condition in children that causes inflammation in muscles and skin, and identifying specific autoantibodies can help classify its subtypes and predict outcomes.
- A case study describes a 5-year-old Moroccan boy with JDM who exhibited symptoms such as dysphagia, facial erythema, muscle weakness, and characteristic skin rashes, along with positive anti-SAE antibodies, a rare finding.
- Treatment involved high-dose methylprednisolone followed by a tapering dose of oral prednisone, highlighting the need for targeted therapies based on specific antibody presence in JDM.
Association between periungual changes and myositis-specific autoantibodies in patients with idiopathic inflammatory myopathies: A retrospective cohort study.
J Am Acad Dermatol
September 2024
Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan.
Comparison of dermoscopic characteristics on toenail onychomycosis in psoriatic and non-psoriatic patients: A prospective study.
Mycoses
April 2024
Department of Dermatology, Peking University First Hospital, Beijing, China.
Article Synopsis
- Psoriatic patients often have onychomycosis (OM), but evaluating it in them is complicated due to possible differences from non-psoriatic cases.
- This study examined the dermoscopic features of toenail OM in 183 psoriatic patients compared to 232 non-psoriatic patients from 2020 to 2023, revealing significant differences in appearance.
- Results showed psoriatic toenail OM had more pitting and periungual telangiectasis, while non-psoriatic cases had features like nail spikes and yellow structureless areas, indicating distinct characteristics between the two groups.
Disease-associated immune cell endotypes in anti-MDA5-positive dermatomyositis using unbiased hierarchical clustering.
Front Immunol
March 2024
Department of Rheumatology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Objective: Clinical and prognostic features of Anti-MDA5-Positive Dermatomyositis (MDA5+ DM) are diverse. This study aimed to examine the peripheral immune cell profiles of patients with MDA5+ DM, identify disease endotypes related to the heterogeneous manifestations and prognosis, and guide individualized therapy regimen.
Methods: This inpatient cohort included 123 patients with MDA5+ DM.
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