Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/cid/civ703 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Laparoscopic varicocelectomy: Does intraoperative lymphography with vital dye influence the outcome?
J Pediatr Urol
December 2024
Pediatric Urology Unit, Bambino Gesù Children Hospital and Research Center IRCCS, Rome, Italy.
Introduction: Vital dyes lymphography during laparoscopic varicocelectomy (LV) has been suggested to allow for lymphatic mapping thereby allowing for lymphatic sparing (LS) and subsequent reduction of hydrocele formation. Intratesticular injection of the dye seems to achieve the best lymphatic visualization, however, the potential toxicity of some agents, is a cause of concern for the risk of testicular pathological changes. We report our experience with LV, to test the hypothesis that Intraoperative lymphography with methylene blue (BL), is safe and reduces the rate of post-operative hydrocelectomy.
View Article and Find Full Text PDFPoint of view: Challenges in implementation of new immunotherapies for Alzheimer's disease.
J Prev Alzheimers Dis
January 2025
Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, BioClinicum, 171 64 Solna, Sweden; Theme Inflammation and Aging, Karolinska University Hospital, 141 86 Stockholm, Sweden.
The advancement of disease-modifying treatments (DMTs) for Alzheimer's disease (AD), along with the approval of three amyloid-targeting therapies in the US and several other countries, represents a significant development in the treatment landscape, offering new hope for addressing this once untreatable chronic progressive disease. However, significant challenges persist that could impede the successful integration of this class of drugs into clinical practice. These challenges include determining patient eligibility, appropriate use of diagnostic tools and genetic testing in patient care pathways, effective detection and monitoring of side effects, and improving the healthcare system's readiness by engaging both primary care and dementia specialists.
View Article and Find Full Text PDFLong-term Outcomes of Definitive Chemoradiation with Proton Therapy for Treatment of Carcinoma of the Anal Canal: Combined Analysis of Two Prospective Trials.
Int J Radiat Oncol Biol Phys
January 2025
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:
Purpose/objective(s): While definitive chemoradiation (CRT) with 5-FU/MMC remains the standard of care for localized anal cancer, treatment is associated with significant acute and late toxicity. Proton radiation therapy (RT) may potentially reduce such toxicity. Here, we assess the long-term outcomes of anal cancer patients treated with CRT using proton RT in two prospective pilot studies.
View Article and Find Full Text PDFMachine Learning Assessment of Dredging Impacts on the Phytoplankton Community on the Brazilian Equatorial Margin: A Multivariate Analysis.
Environ Pollut
January 2025
Federal Institute of Maranhão, Campus Barreirinhas, Rodovia MA-225, KM 04, CEP:65590-000, Barreirinhas, Maranhão, Brazil.
Dredging in estuarine systems significantly impacts phytoplankton communities, with suspended particulate matter (SPM) and dissolved aluminum (Al) serving as indicators of disturbance intensity. This study assessed the effects of dredging in the São Marcos Estuarine Complex (SMEC), Brazil, over three distinct events (2015, 2017, 2020), involving varying sediment volumes and climatic influences. Prolonged dredging operations and increased sediment volumes led to a pronounced 43.
View Article and Find Full Text PDFChronic traumatic brain injury induces neurodegeneration, neuroinflammation, and cognitive deficits in a T cell-dependent manner.
Brain Res
January 2025
Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. Electronic address:
Traumatic brain injury (TBI) can lead to chronic neuroinflammation, and neurodegeneration associated with long-term cognitive deficits. Following TBI, the acute neuroinflammatory response involves microglial activation and the release of proinflammatory cytokines and chemokines which induce the recruitment of peripheral immune cells such as monocytes and ultimately T cells. Persistent innate and adaptive immune cells response can lead to chronic neurodegeneration and functional deficits.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!