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Genetic Variation in , , , , and Confers Differential Susceptibility to Resistant Hypertension among South Africans.
J Pers Med
June 2024
Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town 7700, South Africa.
Resistant hypertension (RHTN) prevalence ranges from 4 to 19% in Africa. There is a paucity of data on the role of genetic variation on RHTN among Africans. We set out to investigate the role of polymorphisms in , , , , and , on RHTN susceptibility among South Africans.
View Article and Find Full Text PDFFunctional polymorphisms of the mineralocorticoid receptor gene NR3C2 are associated with diminished memory decline: Results from a longitudinal general-population study.
Mol Genet Genomic Med
September 2020
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Background: The mineralocorticoid receptor (MR) in the brain has a key role in the regulation of the central stress response and is associated with memory performance. We investigated whether the genetic polymorphisms rs5522 and rs2070951 of NR3C2 showed main and interactive effects with childhood trauma on memory decline.
Methods: Declarative memory was longitudinally assessed in 1,318 participants from the community-dwelling Study of Health in Pomerania using the Verbal Learning and Memory Test (VLMT).
Genetic variation of the mineralocorticoid receptor gene (MR, NR3C2) is associated with a conceptual endophenotype of "CRF-hypoactivity".
Psychoneuroendocrinology
July 2019
Division of Internal Medicine, Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.
Recently, the "conceptual endophenotype" approach has been proposed as a means to identify subgroups of patients affected by stress-related psychiatric disorders. Conceptual endophenotypes consist of patterns of psychological, biological, and symptomatic elements. We studied a sample of patients seeking help for psychosomatic and stress-related disorders (total N = 469), who were evaluated with a diagnostic instrument that integrates psychological and biological data to derive 13 endophenotypes, or Neuropattern.
View Article and Find Full Text PDFNR3C2 Gene is Associated with Susceptibility to High-Altitude Pulmonary Edema in Han Chinese.
Wilderness Environ Med
December 2018
Research Center for High Altitude Medical Sciences, School of Medicine, Qinghai University, Qinghai, China (Drs Yang, Tang, Ga, and Ge); Basic and Applied Key Laboratory for High Altitude Medical Science and Technology of Qinghai, Qinghai, China (Drs Yang, Tang, Ga, and Ge); Qinghai-Utah United Key Laboratory for High Altitude Medical Science, Qinghai, China (Drs Yang, Tang, Ga, and Ge).
Introduction: The mineralocorticoid receptor is encoded by the NR3C2 gene and plays an important role in regulating vascular tone in high-altitude pulmonary edema (HAPE). This study aimed to investigate the association of the polymorphisms in the NR3C2 gene with HAPE susceptibility in Han Chinese.
Methods: We enrolled 133 HAPE patients and 131 matched healthy Han Chinese from the Yushu area in Qinghai, where the altitude is greater than 3500 m.
A Haplotype Associated with Enhanced Mineralocorticoid Receptor Expression Facilitates the Stress-Induced Shift from "Cognitive" to "Habit" Learning.
eNeuro
July 2018
Department of Cognitive Psychology, University of Hamburg, Hamburg 20146, Germany.
Stress induces a shift from hippocampus-dependent "cognitive" toward dorsal striatum-dependent "habit" memory. However, not all individuals are susceptible to this shift under stress. Based on pharmacological studies indicating a critical role of the mineralocorticoid receptor (MR) in the stress-induced bias toward dorsal striatal learning, we hypothesized that gene variants contribute to these individual differences.
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