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Assessment of pathogenic yeast species in the oral cavity of dogs: Antifungal susceptibility and implications for human health.
Res Vet Sci
December 2024
Programa de Pós-Graduação Stricto sensu em Biociência Animal, Universidade de Cuiabá (UNIC), Cuiabá, MT, Brazil.
Companions' animals can present a risk for the transmission of opportunistic diseases to their owners, including those caused by yeasts of the Candida genus residing in their oral microbiota. This study aimed to isolate and identify yeasts from the oral cavity of dogs and assess their susceptibility to antifungals. Yeast species were identified using automated methods MALDI-TOF-MS and VITEK 2 from 50 dogs (aged 2-4 years, various breeds).
View Article and Find Full Text PDFIdentification of the cell-surface lectin domain-containing protein expressed in the adhesive colony morphology of Trichosporon asahii.
Med Mycol
December 2024
Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Shonan University of Medical Sciences, Yokohama, Japan.
Trichosporon asahii is a yeast pathogen that causes a deep-seated infection. In fungal infections, molecules involved in adhesion to host tissues or catheters are one of the pathogenic factors. A single strain of T.
View Article and Find Full Text PDFStrategy to Identify Virulence-Related Genes of the Pathogenic Fungus Trichosporon asahii Using an Efficient Gene-Targeting System.
Microbiol Immunol
December 2024
Department of Microbiology, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan.
Article Synopsis
- Trichosporon asahii is a harmful fungus that primarily affects people with weakened immune systems, leading to severe infections.
- Researchers faced challenges in studying its virulence due to the absence of effective animal models and genetic tools specific to this fungus.
- The study introduces a new method using silkworms for infection testing and a genetic technique to create mutants, aiding in the discovery of virulence factors associated with T. asahii.
Investigation of anticancer potential of a novel bioactive molecule from Trichosporon asahii VITSTB1 in breast cancer cell lines: an in vitro study.
Med Oncol
November 2024
Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Article Synopsis
- The study examines the anticancer potential of yeast-derived proteins against breast cancer, highlighting their immune-stimulating properties and antioxidant effects.
- The research employs various methods, including protein purification and MTT assays, to evaluate the cytotoxic effects of these proteins on MCF-7 breast cancer cells, demonstrating significant anticancer activity with an IC value of 54.89 µg/ml.
- Results indicate that Trichosporon asahii VITSTB1 proteins may offer a promising avenue for cancer treatment, but further research is needed to explore their mechanisms of action and effectiveness in combination with current therapies.
Role of Hog1-mediated stress tolerance in biofilm formation by the pathogenic fungus Trichosporon asahii.
Sci Rep
November 2024
Department of Microbiology, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo, 204-8588, Japan.
Article Synopsis
- Trichosporon asahii is a fungus that can cause bloodstream infections in immunocompromised patients, especially those with low white blood cell counts (neutropenia).
- The fungus can switch between yeast and hyphal forms, forming biofilms on medical devices like catheters, a process potentially influenced by a protein called Hog1.
- Research revealed that a mutant strain of T. asahii lacking the hog1 gene produced more biofilm in rich lab conditions but less in living models like silkworms, indicating that Hog1 plays a crucial role in biofilm formation under different environmental stresses.
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