AI Article Synopsis
- Four new compounds, menisdaurins B-E (1-4), were discovered from the hypocotyl of the mangrove Bruguiera gymnorrhiza, alongside three known derivatives (5-7).
- The structures of these compounds were determined using detailed spectroscopic techniques.
- All seven compounds demonstrated varying levels of anti-Hepatitis B virus activity, with effective concentrations (EC50) ranging between 5.1 and 87.7 μg/mL.
Article Abstract
Four new cyclohexylideneacetonitrile derivatives 1-4, named menisdaurins B-E, as well as three known cyclohexylideneacetonitrile derivatives--menisdaurin (5), coclauril (6), and menisdaurilide (7)--were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-7 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332330 | PMC |
| http://dx.doi.org/10.3390/molecules200814565 | DOI Listing |
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