AI Article Synopsis
- PEEK materials, used in orthopedic surgery, face challenges in bone adhesion due to their low biocompatibility, prompting this study to investigate the impact of titanium and calcium phosphate (CaP) coatings on bone tissue adhesion.
- In a study with six adult sheep, three types of PEEK dowels were implanted: uncoated (control), with CaP coating, and with titanium coating, and then analyzed after different time intervals.
- The results showed that titanium-coated PEEK dowels had significantly greater bone implant contact and bone volume compared to uncoated dowels, indicating that titanium coating enhances the adhesion of bone tissue to these implants.
Article Abstract
Background And Aim: Polyetheretherketone (PEEK) materials already have been used successfully in orthopedic and especially spine surgery. PEEK is radiolucent and comparable with bone regarding elasticity. However, PEEK is inert and the adhesion of PEEK implants to bone tissue proceeds slowly because of their relatively low biocompatibility. The aim of the study is to evaluate the effect of titanium and CaP coating on the adhesion of bone tissue.
Material And Methods: Six adult sheep (body weight 57.6 ± 3.9 kg) were included in this study. Three different types of cylindrical dowels (12 mm length x 8 mm diameter) were implanted in long bones (tibia and femur): PEEK dowels without coating (the control group), and PEEK dowels with a nanocoating of calcium phosphate (CaP group) or titanium (titanium group). Animals were sacrificed after 6, 12 and 26 weeks. Dowels were explanted for micro CT and histology.
Results: Bone implant contact (BIC) ratio was significantly higher in the titanium versus control groups in the 6 to 12 weeks period (p = 0.03). The ratio between bone volume and tissue volume (BV/TV) was significantly higher in titanium versus control in the 6 to 12 weeks period (p = 0.02). A significant correlation between BIC and BV/TV was seen (r = 0.85, p < 0.05).
Conclusion: Coating of PEEK dowels with a nanocoating of titanium has beneficial effects on adhesion of bone tissue.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528570 | PMC |
| http://dx.doi.org/10.14444/2035 | DOI Listing |
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