Objective: To assess the relative contribution of caries and periodontal disease to tooth loss over 24 years in a cohort deprived of regular dental care.
Material & Methods: The study population consisted of 98 subjects from a tea estate on West Java, Indonesia, that had been part of a prospective longitudinal study and provided full datasets of clinical assessments between 1987, 1994 and 2002. In 2011, complete sets of dental radiographs were made which was combined with the survey forms and clinical slides from the previous assessments in order to estimate reasons for tooth loss.
Results: Thirty-seven subjects lost no teeth, whereas 61 subjects lost 185 teeth. In this group, 45.9% lost ≤2 teeth, 32.8% lost 3 to 4 teeth and 19.7% lost ≥5 teeth. The majority of teeth were lost due to caries. In five subjects, tooth loss could be attributed solely to periodontitis, whereas in four subjects teeth were lost due to both caries and periodontits. Analyses of the predictor variables age, gender, smoking, education, presence of caries and severe periodontitis showed that male gender and caries were significantly associated with tooth loss.
Conclusion: The majority of teeth in this population were lost due to caries.
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http://dx.doi.org/10.1111/jcpe.12446 | DOI Listing |
PLoS Genet
January 2025
Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Inositol 1,4,5-trisphosphate receptors (IP3R) mediate Ca2+ release from intracellular stores, contributing to complex regulation of numerous physiological responses. The involvement of the three IP3R genes (ITPR1, ITPR2 and ITPR3) in inherited human diseases has started to shed light on the essential roles of each receptor in different human tissues and cell types. Variants in the ITPR3 gene, which encodes IP3R3, have recently been found to cause demyelinating sensorimotor Charcot-Marie-Tooth neuropathy type 1J (CMT1J).
View Article and Find Full Text PDFSwiss Dent J
January 2025
Division of Gerodontology and Removable Prosthodontics, University Clinics of Dental Medicine, University of Geneva, Geneva, Switzerland.
Due to effective preventive measures and advanced techniques in operative dentistry, tooth loss occurs later in life and implant restorations have become a common solution for replacement of missing teeth. Therefore, the use of removable dental prostheses (RDPs) is expected to decline over time. This study aims to evaluate the expected decrease in the production of RDPs in Swiss dental laboratories over the past decade.
View Article and Find Full Text PDFJ Clin Periodontol
January 2025
Department of Periodontology, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Aim: Masticatory dysfunction due to tooth loss is a potentially modifiable risk for mortality, but the pathway behind that remains to be investigated. This prospective study aimed to examine the role of diet and ageing in the associations between chewing capacity and long-term mortality.
Methods: Data were obtained from participants (aged ≥ 20) in the National Health Nutritional and Health Survey (NHANES 1999-2010, n = 22,900).
Int J Oral Maxillofac Surg
January 2025
Stomatological Hospital of Chongqing Medical University, Chongqing, China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China. Electronic address:
The retrospective study aimed to compare the space-maintaining effects of sticky bone (bone graft matrix enriched with injectable platelet-rich fibrin) and titanium mesh for bone augmentation in the aesthetic zone. Patients who underwent single implant placement and had type 2/4 alveolar bone defects (buccal bone wall loss is >50% of the expected implant length) were screened for inclusion in this study. The labial bone plate width was measured at 1, 3, and 5 mm below the apical implant platform on cone beam computed tomography images taken immediately and 6 months after surgery.
View Article and Find Full Text PDFHGG Adv
January 2025
Department of Surgery, Division of Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address:
SOX9 encodes an SRY-related transcription factor critical for chondrogenesis and sex determination among other processes. Loss-of-function variants cause campomelic dysplasia and Pierre Robin Sequence, while both gain- and loss-of-function variants cause disorders of sex development. SOX9 has also been linked to scoliosis and cancers, but variants are undetermined.
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