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Protection induced by recombinant vaccinia virus targeting the ROP4 of Toxoplasma gondii in mice.
Exp Parasitol
January 2025
Department of Medical Zoology, School of Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea; Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, Core Research Institute (CRI), Kyung Hee University, Seoul, 02447, Republic of Korea. Electronic address:
Toxoplasmosis is a parasitic disease affecting a significant portion of the global population, whose etiology can be attributed to the protozoan organism Toxoplasma gondii. Despite its public health importance, an efficacious vaccine to prevent human toxoplasmosis remains unavailable. To this end, we designed an experimental toxoplasmosis vaccine using recombinant vaccinia virus vectors (rVacv) expressing the T.
View Article and Find Full Text PDFEffectiveness of Using Checklist in Preventing Facial, Nasal and Head Pressure Injuries in Preterm Infants in Nasal Noninvasive Mechanic Ventilation: A Quasi-Experimental Study.
J Perinat Neonatal Nurs
October 2024
Author Affiliations: Department of Child Health and Diseases Nursing (Dr Güner Başara), Faculty of Health Sciences, Gaziosmanpaşa University, Tokat, Turkey; and Department of Child Health and Diseases Nursing, Faculty of Nursing (Dr Çalışır), Department of Neonatology, Faculty of Medicine (Dr Kaynak Türkmen, retired), Aydın Adnan Menderes University, Aydın, Turkey.
Background: Noninvasive mechanical ventilation (NIMV), when in synchronized intermittent mandatory ventilation, continuous positive airway pressure, or patient-triggered ventilation modes, is known to be a cause of facial, nasal, head, and skin pressure injuries in preterm infants.
Objective: The objective of this study is to examine the efficacy of using a checklist with preterm infants under nasal NIMV in preventing facial, nasal, and head pressure injuries.
Method: The study was conducted quasi-experimentally on preterm infants under NIMV.
Association between the correct use of intranasal aerosols and symptom improvement in allergic rhinitis.
Allergol Immunopathol (Madr)
January 2025
Regional Center for Allergy and Clinical Immunology, University Hospital "Dr. José Eleuterio González" Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico;
Objective: Allergic rhinitis (AR) is highly prevalent worldwide. Good patient adherence ensures successful treatment. This study aimed to identify the association between the intranasal aerosol technique and symptom improvement.
View Article and Find Full Text PDFSafety, Immunogenicity and Protective Activity of a Modified Trivalent Live Attenuated Influenza Vaccine for Combined Protection Against Seasonal Influenza and COVID-19 in Golden Syrian Hamsters.
Vaccines (Basel)
November 2024
Institute of Experimental Medicine, Saint Petersburg 197022, Russia.
Background/objectives: Influenza viruses and SARS-CoV-2 are currently cocirculating with similar seasonality, and both pathogens are characterized by a high mutational rate which results in reduced vaccine effectiveness and thus requires regular updating of vaccine compositions. Vaccine formulations combining seasonal influenza and SARS-CoV-2 strains can be considered promising and cost-effective tools for protection against both infections.
Methods: We used a licensed seasonal trivalent live attenuated influenza vaccine (3×LAIV) as a basis for the development of a modified 3×LAIV/CoV-2 vaccine, where H1N1 and H3N2 LAIV strains encoded an immunogenic cassette enriched with conserved T-cell epitopes of SARS-CoV-2, whereas a B/Victoria lineage LAIV strain was unmodified.
IL-1β-driven NF-κB transcription of ACE2 as a Mechanism of Macrophage Infection by SARS-CoV-2.
bioRxiv
December 2024
Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.
Coronavirus disease 2019 (COVID-19), caused by infection with the enveloped RNA betacoronavirus, SARS-CoV-2, led to a global pandemic involving over 7 million deaths. Macrophage inflammatory responses impact COVID-19 severity; however, it is unclear whether macrophages are infected by SARS-CoV-2. We sought to identify mechanisms regulating macrophage expression of ACE2, the primary receptor for SARS-CoV-2, and to determine if macrophages are susceptible to productive infection.
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