AI Article Synopsis
- Myocardial infarction (MI) is a major cause of death in developed countries, linked with various symptoms and decreased quality of life, and recent studies indicate a relationship between heart issues and brain inflammation.
- Researchers examined the effects of MI on specific brain cells (microglia and astrocytes) in sedentary and trained rats, discovering notable changes in these cells 48 hours post-MI.
- Prolonged exercise was found to reverse some of the brain changes caused by MI, particularly in areas like the prefrontal cortex, hippocampus, and thalamus, suggesting that physical activity can help mitigate brain inflammation related to heart problems.
Article Abstract
Myocardial infarction (MI) is one of the leading causes of death in developed countries and it is characterized by several associated symptomatologies and poor quality of life. Recent data showed a possible interaction between infarction and brain inflammation and activity. Previous studies have demonstrated the beneficial effect of exercise training on deterioration in cardiac function after MI. In this study we analyzed in sedentary and trained rats the microglia and astrocytes 48 hours after MI in PVN, thalamus, prefrontal cortex, and hippocampus through immunofluorescence approach. We found significant changes in specific microglia phenotypes in the brain areas analyzed together with astrocytes activation. Prolonged exercise normalized these morphological changes of microglia and astrocytes in the prefrontal cortex, hippocampus, and thalamus but not in the PVN. Our data suggest that there is an early brain reaction to myocardial infarction induction, involving nonneuronal cells, that is attenuated by the prolonged exercise.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526216 | PMC |
| http://dx.doi.org/10.1155/2015/265967 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!