Badger submandibular glands contain a double-headed secretory proteinase inhibitor. Its amino acid sequence was determined. Extensive homologies were found between this inhibitor and the corresponding inhibitors of fox, dog, lion and cat in both domains. As in fox and dog inhibitor, the trypsin-inhibiting domain of badger inhibitor contains an Arg residue in the reactive site in contrast to a Lys residue in the inhibitors of lion and cat. Domains I and II of badger inhibitor are structurally related both to the sequenced inhibitors of fox, dog, lion and cat and to the sequenced monovalent secretory pancreatic trypsin inhibitors. The sequence of the badger inhibitor is N-terminally extended by four amino acids in comparison to fox and dog inhibitors and extended by eight amino acids in comparison to lion and cat inhibitors. Furthermore, the badger inhibitor is C-terminally extended by two amino acids in comparison to the lion inhibitor and by three amino acids in comparison to all other sequenced inhibitors.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Natural life cycle and molecular characterization of Dollfus, 1960 (Cestoda: Taeniidae) from northwestern Patagonia, Argentina.
Int J Parasitol Parasites Wildl
April 2025
División Zoología Invertebrados, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, CONICET-Centro Científico Tecnológico La Plata, Buenos Aires. Paseo del Bosque s/n La Plata, (1900), Buenos Aires, Argentina.
Through morphological and molecular studies, the natural life cycle of Dollfus, 1960 (Cestoda: Taeniidae) from Argentine Patagonia is elucidated, involving subterranean rodents (Ctenomyidae) as intermediate hosts, and the Andean fox (Canidae) as definitive host. Metacestodes (mono- and polycephalic fimbriocerci) were found mainly in the peritoneal cavity of , and the strobilate adult in the intestine of . Correspondence between metacestodes and strobilate adults was based primarily on number, size and shape of rostellar hooks: 45-53 hooks alternated in two rows, small hooks 88-180 μm long and large hooks 230-280 μm long, with the characteristic shape described in the two main description of the species, both that of the metacestode (original description) and that of the strobilate adult (obtained experimentally).
View Article and Find Full Text PDFComplete genome sequence of the first strain isolated from a red fox () in Germany.
Microbiol Resour Announc
January 2025
Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
The zoonotic pathogen is part of the oral microbiome of dogs and cats. We report the genome sequence of strain KM3195_24, isolated from a red fox. It has a circular genome of 2,718,701 bp with a G + C content of 36%, 2,419 CDS, 3 rRNA operons, and 45 tRNAs.
View Article and Find Full Text PDFEpidemiology, transmission dynamics, risk factors, and future directions of rabies in the Arabian Peninsula using one health approach: a review.
Eur J Public Health
January 2025
Health Protection and Communicable Diseases Department, Ministry of Public Health, Doha, Qatar.
Despite global initiatives to eliminate dog-mediated human rabies by 2030, the Arabian Peninsula faces challenges due to insufficient data. This review addresses the current rabies situation and knowledge gaps in the region and proposes One Health interventions. Employing a mixed-method approach combining scoping and systematic review, the study commenced with a Delphi discussion to identify knowledge gaps and set objectives.
View Article and Find Full Text PDFα-Catenin force-sensitive binding and sequestration of LZTS2 leads to cytokinesis failure.
J Cell Biol
March 2025
Department of Pulmonary Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Epithelial cells can become polyploid upon tissue injury, but mechanosensitive cues that trigger this state are poorly understood. Using an Madin Darby Canine Kidney (MDCK) cell knock-out/reconstitution system, we show that α-catenin mutants that alter force-sensitive binding to F-actin or middle (M)-domain promote cytokinesis failure and binucleation, particularly near epithelial wound-fronts. We identified Leucine Zipper Tumor Suppressor 2 (LZTS2), a factor previously implicated in abscission, as a conformation sensitive proximity partner of α-catenin.
View Article and Find Full Text PDFMitochondrial Genomes of Mammals from the Brazilian Cerrado and Phylogenetic Considerations for the Orders Artiodactyla, Carnivora, and Chiroptera (Chordata: Mammalia).
Life (Basel)
December 2024
Laboratory of Bioinformatics and Genomics, Federal University of Viçosa, Rio Paranaíba 38810-000, MG, Brazil.
We assembled and annotated the complete mitochondrial genomes of (hoary fox), (bush dog), (white-lipped peccary), and (Brazilian free-tailed bat). The mitogenomes exhibited typical vertebrate structures, containing 13 protein-coding genes, 22 tRNA genes, 2 ribosomal RNA genes, and a D-loop region. Phylogenetic reconstruction using the 13 protein-coding genes revealed robust relationships among species within Carnivora, Chiroptera, and Artiodactyla, corroborating previous studies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!