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Discriminating necrotising enterocolitis and focal intestinal perforation.
Arch Dis Child Fetal Neonatal Ed
May 2022
Neonatology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.
Discriminating necrotising enterocolitis (NEC) and focal intestinal perforation (FIP) is important for clinical trials, observational cohorts, quality improvement and aetiological understanding. Literature suggests that timing and key features diagnose and discriminate, and that NEC subclassifications exist. We used a detailed 10-year cohort of NEC and FIP cases in preterm infants born <32 weeks' gestation from a single centre to explore antecedent factors, presentation and potential NEC subclassifications.
View Article and Find Full Text PDFTransfusion-associated circulatory overload-a systematic review of diagnostic biomarkers.
Transfusion
February 2019
Department of Intensive Care Medicine, Amsterdam University Medical Centers-AMC, Amsterdam, The Netherlands.
Background: Transfusion-associated circulatory overload (TACO) is the leading cause of transfusion-related major morbidity and mortality. Diagnosing TACO is difficult because there are no pathognomonic signs and symptoms. TACO biomarkers may aid in diagnosis, decrease time to treatment, and differentiate from other causes of posttransfusion dyspnea such a transfusion-related acute lung injury.
View Article and Find Full Text PDFMortality associated with standard prescription transfusions in cardiac surgery.
Hippokratia
January 2018
Blood Bank Service, University Hospital of Ioannina, Ioannina, Hellas.
Background: Before applying new blood management strategies, the extent of blood product transfusions and its correlation with perioperative mortality should be identified.
Methods: This study retrospectively analyzed the extent of perioperative transfusions of red blood cells (RBC), fresh frozen plasma (FFP), and platelets (PLT) in 565 consecutive cardiac surgery patients, who received transfusions based on standard prescriptions. Patients were stratified in four groups according to perioperative transfusion units (no transfusion, <5, 5-10, >10 units).
Discriminating different causes of transfusion-associated pulmonary edema.
Transfusion
August 2015
Department of Pathology & Laboratory Medicine, Rhode Island Hospital and the Miriam Hospitals, Providence, RI.
Risk scores to facilitate preoperative prediction of transfusion and large volume blood transfusion associated with adult cardiac surgery.
Br J Anaesth
May 2015
Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester LE3 9QP, UK
Background: The aim of this study was to develop two novel risk prediction scores for transfusion and bleeding that would be used to inform treatment decisions, quality assurance, and clinical trial design in cardiac surgery.
Methods: Clinical data prospectively collected from 26 UK cardiac surgical centres and a single European centre were used to develop two risk prediction models: one for any red blood cell (RBC) transfusion, and the other for large volume blood transfusion (≥4 RBC units; LVBT), an index of severe blood loss. 'Complete case' data were available for 24 749 patients.
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