Non-coding RNAs (ncRNAs) play regulatory roles at all stages of the genetic information transmission from DNA to proteins. The ncRNA-mediated mechanisms leading to specific expression or silencing of particular genes seem to be of special importance. In addition to well-known and well-understood functions of RNAs, we recently discover new and nonobvious aspects and possibilities of regulating cellular processes. One example is the processing of various RNAs, the mechanism of formation of short non-coding RNAs from existing functional RNAs. Both: the sources of these short RNAs and the functions performed by them are diverse. Their presence greatly enriches the possibilities of gene expression regulation, as it turns out, at all stages.
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Viruses
December 2024
HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892, USA.
Gammaherpesviruses are oncogenic pathogens that establish lifelong infections. There are no FDA-approved vaccines against Epstein-Barr virus or Kaposi sarcoma herpesvirus. Murine gammaherpesvirus-68 (MHV68) infection of mice provides a system for investigating gammaherpesvirus pathogenesis and testing vaccine strategies.
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November 2024
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Kaposi's sarcoma-associated herpesvirus (KSHV), a γ-herpesvirus, is predominantly associated with Kaposi's sarcoma (KS) as well as two lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). Like other herpesviruses, KSHV employs two distinct life cycles: latency and lytic replication. To establish a lifelong persistent infection, KSHV has evolved various strategies to manipulate the epigenetic machinery of the host.
View Article and Find Full Text PDFNutrients
December 2024
AdventHealth Ocala, 1500 SW 1st Ave, Ocala, FL 34471, USA.
An increasing number of studies highlight the critical role of both maternal and paternal nutrition and body weight before conception in shaping offspring health. Traditionally, research has focused on maternal factors, particularly in utero exposures, as key determinants of chronic disease development. However, emerging evidence underscores the significant influence of paternal preconception health on offspring metabolic outcomes.
View Article and Find Full Text PDFPathogens
December 2024
Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
More than one-hundred species that affect animals and humans have been described, eight of which have been associated with emerging and underdiagnosed zoonoses. Most diagnostic studies in humans have used serology or molecular assays based on the 18S rRNA gene. Because the 18S rRNA gene is highly conserved, obtaining an accurate diagnosis at the species level is difficult, particularly when the amplified DNA fragment is small.
View Article and Find Full Text PDFInsects
December 2024
Laboratorio de Fisiología Molecular y Estructural, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza 64460, Mexico.
The parasitoid wasp (Howard) (Hymenoptera: Pteromalidae) has the potential for biological control against insect pests in stored grains, mainly of the orders Coleoptera and Lepidoptera. microRNAs (miRNAs) are small non-coding RNA fragments of importance in the regulation of gene translation in most physiological processes, and the study of miRNAs in wasps can be useful for understanding the physiology of these insects. The objective of this study was to evaluate for the first time the miRNomic profile of and to determine its conservation in five species of the order Hymenoptera (, , , and ).
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