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Interaction between Vitamin D homeostasis, gut microbiota, and central precocious puberty.
Front Endocrinol (Lausanne)
December 2024
Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Central precocious puberty (CPP) is an endocrine disease in children, characterized by rapid genital development and secondary sexual characteristics before the age of eight in girls and nine in boys. The premature activation of the hypothalamic-pituitary-gonadal axis (HPGA) limits the height of patients in adulthood and is associated with a higher risk of breast cancer. How to prevent and improve the prognosis of CPP is an important problem.
View Article and Find Full Text PDFNovel approach to bone comorbidity in resistant acromegaly.
Pituitary
December 2024
Institute of Endocrine and Metabolic Sciences, Università Vita-Salute San Raffaele, Via Olgettina, 58, Milan, 20132, Italy.
Article Synopsis
- Active acromegaly can cause serious, irreversible complications like osteopathy and fragile fractures, which are linked to longer disease duration and high growth hormone levels.
- Unlike primary osteoporosis, bone mineral density isn't a good predictor for fracture risk in acromegaly patients, as they often have normal or only slightly reduced bone mass, but compromised bone quality.
- The manuscript aims to review evidence on skeletal fragility in patients with active and resistant acromegaly, highlighting the need for disease control and potential protective effects from vitamin D and pasireotide therapies.
Safety and Efficacy of Cinacalcet in Children Aged Under 3 Years on Maintenance Dialysis.
Kidney Int Rep
July 2024
Department of Pediatric Nephrology, Rheumatology and Dermatology, Reference Center for Rare Renal Diseases, Reference Center for Rare Diseases of Phosphate and Calcium, Femme Mère Enfant Hospital, Hospices Civils de Lyon, Lyon, France.
Introduction: Secondary hyperparathyroidism (sHPT) is particularly severe in rapidly growing infants in dialysis. Although cinacalcet is effective and licensed in dialysis in children aged >3 years, its efficacy and safety for children aged <3 years is unknown.
Methods: We identified 26 children aged <3 years who were on dialysis and treated with cinacalcet between 2009 and 2021 in 8 European pediatric centers.
Background: The association between 25(OH)D and pubertal timing has not been well studied. The aim of this study was to assess the relationship between 25(OH)D levels and pubertal timing in children.
Methods: Participants aged 6-14 years who had available nutritional and serum sex hormone (total testosterone (TT) and estradiol (E2)) information (n =1318) were included.
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