DMPU/HF (HF content 65 wt %/wt) is an ideal nucleophilic fluorination reagent for the diastereoselective synthesis of substituted 4-fluorotetrahydropyrans and 4-fluoropiperidines via a fluoro-Prins reaction. When compared to classical nucleophilic fluorination reagents like pyridine/HF, DMPU/HF gives both higher yields and better diastereoselectivity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381514 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.5b01919 | DOI Listing |
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