AI Article Synopsis
- A study was conducted to create a canine model of crush syndrome using 16 healthy female Beagle dogs, divided into a control group and an experimental group.
- The experimental group had crush injuries applied to their left hind leg, leading to significant biochemical changes and kidney damage compared to both their pre-injury values and the control group.
- The successful establishment of this model allows for further research into the mechanisms and treatments of crush syndrome.
Article Abstract
Objective: To establish a canine model of crush syndrome (CS).
Methods: A total of 16 healthy adult female Beagle dogs were randomly divided into the control group (n=8) and the experimental group (n=8). The crush injury was created in the left hind leg of each dog in the experimental group.
Results: The biochemical indexes in the experimental group changed significantly compared to the values before extrusion. And they were also significantly different from the values of the control group. The glomerular capillary dilation, renal tubular epithelial cell degeneration, and renal interstitial lymphocytic infiltration were found in the kidneys.
Conclusion: The canine CS model established by the digital crush injury device platform was successful according with the diagnosis of CS. It is good for the investigation of the CS mechanism and treatment using this model.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525823 | PMC |
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