BALB/c nude mice (nu/nu) carrying established human transplantable breast tumors (MX-1) and fed fat from either fish oil (MaxEPA), corn oil, or lard, were treated with either an unconjugated mixture or an 131I-labeled cocktail of Mc1, Mc3, Mc5 and Mc8 four anti-human milk fat globule monoclonal antibodies (MoAbs). MaxEPA diet by itself reduced mean volume of tumor MX-1 to 36% below that of both the corn oil and lard diets. Injection of unconjugated MoAbs reduced tumor volumes only in corn oil fed nude mice when each group was compared to their respective controls. Treatment with 131I-MoAbs produced large tumor volume reductions in all groups with the three different diets. The greatest reduction was obtained with the synergistic effect of MaxEPA and 131I-labeled MoAbs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0022-4731(89)90076-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sustainable Fortification of Corn Tortillas with Broccoli By-Products.
Foods
February 2025
Postharvest and Refrigeration Group, Universidad Politécnica de Cartagena (UPCT), Paseo Alfonso XIII, 48, 30203 Cartagena, Spain.
Fortification is the deliberate addition of essential micronutrients, such as vitamins and minerals, to enhance a food's nutritional profile and contribute to public health. A promising approach to fortification involves the use of plant by-products which are rich in bioactive compounds. This study evaluates the effects of incorporating broccoli by-product powder into corn-flour tortillas.
View Article and Find Full Text PDFPotential of NbO as a Catalyst in Biodiesel Production: A Study with Different Feedstock.
Molecules
February 2025
Laboratory of Ceramic Materials Synthesis, Federal University of Campina Grande, 882 Aprígio Veloso Street-Bodocongó, Campina Grande 58429-900, PB, Brazil.
The objective of this study was to evaluate the catalytic performance of commercial NbO, supplied by CBMM, in the production of biodiesel by transesterification and esterification, using different feedstocks (soybean, corn, sunflower, and waste oils) and both methyl and ethyl routes. For this, the catalyst was characterized in terms of its crystal structure by X-ray diffraction (XRD), specific surface area using the Brunauer-Emmett-Teller (BET) technique, thermal stability by thermogravimetric analysis (TGA), morphology by scanning electron microscopy (SEM), acidity by ammonia desorption at programmed temperature (TPD-NH), and catalytic activity by gas chromatography. The results from the structural analyses indicated that NbO has a single monoclinic phase and a morphology consisting of irregular agglomerates.
View Article and Find Full Text PDFMetabolomic analyses reveal that graphene oxide alleviates nicosulfuron toxicity in sweet corn.
Front Plant Sci
February 2025
College of Agronomy and Biotechnology, Hebei Key Laboratory of Crop Stress Biology, Hebei Normal University of Science and Technology, Qinhuangdao, China.
Nicosulfuron can repress the growth and quality of sweet corn (), and graphene oxide has been used for sustainable agriculture. However, the underlying mechanism of the toxicity of nicosulfuron that is mediated in sweet corn remains elusive. To explore the potential mechanism of GO-mediated nicosulfuron toxicity in sweet corn in this study, we investigated the effects of graphene oxide on nicosulfuron stress in the sweet corn sister inbred lines of H01 and H20.
View Article and Find Full Text PDFCurcumin-loaded Pickering emulsions stabilized by Spanish mackerel protein-pectin for ameliorating ulcerative colitis through barrier repair and anti-inflammatory effects.
Int J Biol Macromol
March 2025
State Key Laboratory of Marine Food Processing and Safety Control, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, Liaoning, China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Dalian Key Laboratory for Precision Nutrition, Dalian Polytechnic University, Dalian 116034, Liaoning, China. Electronic address:
Curcumin (Cur) has gained considerable recognition because of its anti-inflammatory and antioxidant effects as a bioactive compound, but its water insolubility and low bioaccessibility limit its application in food industry. In this study, Pickering emulsion stabilized by Spanish mackerel protein and pectin complex (SMP/PEC) was prepared to deliver curcumin, and its alleviating effects on DSS-induced ulcerative colitis (UC) were investigated. The emulsions stabilized by SMP/PEC 1:1 inhibited phase separation, had good rheological properties and the emulsions were stable at high temperatures, centrifugation, salt ions, and pH conditions.
View Article and Find Full Text PDFDown-regulation of TET2 inhibits testosterone synthesis in offspring mice exposed to DBP during pregnancy through LH/cAMP/PKA/StAR signaling mediated by LHR.
Ecotoxicol Environ Saf
March 2025
School of Public Health, Beihua University, Jilin 132013, China. Electronic address:
Exposure to di-n-butyl phthalate (DBP) during embryo development or lactation has been linked to reproductive toxicity. The ten-eleven translocation (TET) protein family plays a role in various pathological processes; however, its involvement in reproductive dysfunction in offspring mice exposed to DBP during gestation remains sparsely reported. In this study, SPF C57BL/6 pregnant mice were intragastrically administered DBP at doses of 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!